000164659 001__ 164659
000164659 005__ 20230915090555.0
000164659 0247_ $$2doi$$a10.1212/WNL.0000000000200819
000164659 0247_ $$2ISSN$$a0028-3878
000164659 0247_ $$2ISSN$$a1526-632X
000164659 0247_ $$2altmetric$$aaltmetric:135406022
000164659 0247_ $$2pmid$$apmid:35667840
000164659 037__ $$aDZNE-2022-01189
000164659 041__ $$aEnglish
000164659 082__ $$a610
000164659 1001_ $$00000-0002-2172-7386$$aRegensburger, Martin$$b0
000164659 245__ $$aInertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia: A Cross-Sectional Multicenter Clinical Study
000164659 260__ $$a[S.l.]$$bOvid$$c2022
000164659 3367_ $$2DRIVER$$aarticle
000164659 3367_ $$2DataCite$$aOutput Types/Journal article
000164659 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1669641356_31981
000164659 3367_ $$2BibTeX$$aARTICLE
000164659 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000164659 3367_ $$00$$2EndNote$$aJournal Article
000164659 520__ $$aHereditary spastic paraplegia (HSP) causes progressive spasticity and weakness of the lower limbs. As neurological examination and the clinical Spastic Paraplegia Rating Scale (SPRS) are subject to potential patient- and clinician-dependent bias, instrumented gait analysis bears the potential to objectively quantify impaired gait. The aim of the present study was to investigate gait cyclicity parameters by application of a mobile gait analysis system in a cross sectional cohort of HSP patients and a longitudinal fast progressing subcohort.Methods: Using wearable sensors attached to the shoes, HSP patients and controls performed a 4x10 meters walking test during regular visits in three outpatient centers. Patients were also rated according to the SPRS and in a subset, questionnaires on quality of life and fear of falling were obtained. An unsupervised segmentation algorithm was employed to extract stride parameters and respective coefficients of variation.Results: Mobile gait analysis was performed in a total of 112 ambulatory HSP patients and 112 age and gender matched controls. While swing time was unchanged compared to controls, there were significant increases in the duration of the total stride phase and the duration of the stance phase, both regarding absolute values and coefficients of variation values. While stride parameters did not correlate to age, weight or height of the patients, there were significant associations of absolute stride parameters to single SPRS items reflecting impaired mobility (|r| > 0.50), to patients' quality of life (|r| > 0.44), and notably to disease duration (|r| > 0.27). Sensor-derived coefficients of variation, on the other hand, were associated with patient-reported fear of falling (|r| > 0.41) and cognitive impairment (|r| > 0.40). In a small 1-year follow-up analysis of patients with complicated HSP and fast progression, absolute values of mobile gait parameters had significantly worsened compared to baseline.Discussion: The presented wearable sensor system provides parameters of stride characteristics which appear clinically valid to reflect gait impairment in HSP. Due to the feasibility with regard to time, space and costs, the present study forms the basis for larger scale longitudinal and interventional studies in HSP.
000164659 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000164659 588__ $$aDataset connected to CrossRef, Journals: pub.dzne.de
000164659 650_7 $$2Other$$aGait Analysis
000164659 650_7 $$2Other$$aWearables
000164659 650_7 $$2Other$$a[163] Gait disorders/ataxia
000164659 650_7 $$2Other$$a[174] Spastic paraplegia
000164659 7001_ $$aSpatz, Imke Tabea$$b1
000164659 7001_ $$aOllenschläger, Malte$$b2
000164659 7001_ $$aMartindale, Christine F$$b3
000164659 7001_ $$aLindeburg, Philipp$$b4
000164659 7001_ $$aKohl, Zacharias$$b5
000164659 7001_ $$00000-0002-0417-0336$$aEskofier, Björn$$b6
000164659 7001_ $$aKlucken, Jochen$$b7
000164659 7001_ $$0P:(DE-2719)2812018$$aSchüle, Rebecca$$b8$$udzne
000164659 7001_ $$aKlebe, Stephan$$b9
000164659 7001_ $$aWinkler, Jürgen$$b10
000164659 7001_ $$00000-0003-2037-9460$$aGaßner, Heiko$$b11
000164659 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000200819$$gp. 10.1212/WNL.0000000000200819 -$$n10$$pe1079 - e1089$$tNeurology$$v99$$x0028-3878$$y2022
000164659 909CO $$ooai:pub.dzne.de:164659$$pVDB
000164659 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812018$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000164659 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000164659 9141_ $$y2022
000164659 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-27
000164659 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-27
000164659 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-27
000164659 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz$$d2022-11-12$$wger
000164659 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROLOGY : 2021$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12
000164659 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNEUROLOGY : 2021$$d2022-11-12
000164659 9201_ $$0I:(DE-2719)5000024$$kAG Maetzler$$lFunctional Neurogeriatrics$$x0
000164659 980__ $$ajournal
000164659 980__ $$aVDB
000164659 980__ $$aI:(DE-2719)5000024
000164659 980__ $$aUNRESTRICTED