Home > Publications Database > Inertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia: A Cross-Sectional Multicenter Clinical Study > print

001     164659
005     20230915090555.0
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041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Regensburger, Martin
|0 0000-0002-2172-7386
|b 0
245 _ _ |a Inertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia: A Cross-Sectional Multicenter Clinical Study
260 _ _ |a [S.l.]
|c 2022
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520 _ _ |a Hereditary spastic paraplegia (HSP) causes progressive spasticity and weakness of the lower limbs. As neurological examination and the clinical Spastic Paraplegia Rating Scale (SPRS) are subject to potential patient- and clinician-dependent bias, instrumented gait analysis bears the potential to objectively quantify impaired gait. The aim of the present study was to investigate gait cyclicity parameters by application of a mobile gait analysis system in a cross sectional cohort of HSP patients and a longitudinal fast progressing subcohort.Methods: Using wearable sensors attached to the shoes, HSP patients and controls performed a 4x10 meters walking test during regular visits in three outpatient centers. Patients were also rated according to the SPRS and in a subset, questionnaires on quality of life and fear of falling were obtained. An unsupervised segmentation algorithm was employed to extract stride parameters and respective coefficients of variation.Results: Mobile gait analysis was performed in a total of 112 ambulatory HSP patients and 112 age and gender matched controls. While swing time was unchanged compared to controls, there were significant increases in the duration of the total stride phase and the duration of the stance phase, both regarding absolute values and coefficients of variation values. While stride parameters did not correlate to age, weight or height of the patients, there were significant associations of absolute stride parameters to single SPRS items reflecting impaired mobility (|r| > 0.50), to patients' quality of life (|r| > 0.44), and notably to disease duration (|r| > 0.27). Sensor-derived coefficients of variation, on the other hand, were associated with patient-reported fear of falling (|r| > 0.41) and cognitive impairment (|r| > 0.40). In a small 1-year follow-up analysis of patients with complicated HSP and fast progression, absolute values of mobile gait parameters had significantly worsened compared to baseline.Discussion: The presented wearable sensor system provides parameters of stride characteristics which appear clinically valid to reflect gait impairment in HSP. Due to the feasibility with regard to time, space and costs, the present study forms the basis for larger scale longitudinal and interventional studies in HSP.
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650 _ 7 |a Gait Analysis
|2 Other
650 _ 7 |a Wearables
|2 Other
650 _ 7 |a [163] Gait disorders/ataxia
|2 Other
650 _ 7 |a [174] Spastic paraplegia
|2 Other
700 1 _ |a Spatz, Imke Tabea
|b 1
700 1 _ |a Ollenschläger, Malte
|b 2
700 1 _ |a Martindale, Christine F
|b 3
700 1 _ |a Lindeburg, Philipp
|b 4
700 1 _ |a Kohl, Zacharias
|b 5
700 1 _ |a Eskofier, Björn
|0 0000-0002-0417-0336
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700 1 _ |a Klucken, Jochen
|b 7
700 1 _ |a Schüle, Rebecca
|0 P:(DE-2719)2812018
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700 1 _ |a Klebe, Stephan
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700 1 _ |a Winkler, Jürgen
|b 10
700 1 _ |a Gaßner, Heiko
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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