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@ARTICLE{Mestres:164668,
      author       = {Mestres, Ivan and Houtman, Judith and Calegari, Federico
                      and Toda, Tomohisa},
      title        = {{A} {N}uclear {B}elt {F}astens on {N}eural {C}ell {F}ate},
      journal      = {Cells},
      volume       = {11},
      number       = {11},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2022-01198},
      pages        = {1761},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {Successful embryonic and adult neurogenesis require
                      proliferating neural stem and progenitor cells that are
                      intrinsically and extrinsically guided into a neuronal fate.
                      In turn, migration of new-born neurons underlies the complex
                      cytoarchitecture of the brain. Proliferation and migration
                      are therefore essential for brain development, homeostasis
                      and function in adulthood. Among several tightly regulated
                      processes involved in brain formation and function, recent
                      evidence points to the nuclear envelope (NE) and
                      NE-associated components as critical new contributors.
                      Classically, the NE was thought to merely represent a
                      barrier mediating selective exchange between the cytoplasm
                      and nucleoplasm. However, research over the past two decades
                      has highlighted more sophisticated and diverse roles for NE
                      components in progenitor fate choice and migration of their
                      progeny by tuning gene expression via interactions with
                      chromatin, transcription factors and epigenetic factors.
                      Defects in NE components lead to neurodevelopmental
                      impairments, whereas age-related changes in NE components
                      are proposed to influence neurodegenerative diseases. Thus,
                      understanding the roles of NE components in brain
                      development, maintenance and aging is likely to reveal new
                      pathophysiological mechanisms for intervention. Here, we
                      review recent findings for the previously underrepresented
                      contribution of the NE in neuronal commitment and migration,
                      and envision future avenues for investigation. View
                      Full-Text},
      keywords     = {Cell Differentiation: physiology / Cell Nucleus /
                      Neurogenesis: genetics / Neurons: metabolism / Nuclear
                      Envelope: metabolism},
      cin          = {AG Toda},
      ddc          = {570},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9179901},
      pubmed       = {pmid:35681456},
      doi          = {10.3390/cells11111761},
      url          = {https://pub.dzne.de/record/164668},
}