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@ARTICLE{Alfadil:164942,
      author       = {Alfadil, Eissa and Bradke, Frank},
      title        = {{M}oving through the crowd. {W}here are we at understanding
                      physiological axon growth?},
      journal      = {Seminars in cell $\&$ developmental biology},
      volume       = {140},
      issn         = {1084-9521},
      address      = {London},
      publisher    = {Academic Press},
      reportid     = {DZNE-2022-01346},
      pages        = {63-71},
      year         = {2023},
      note         = {CC BY},
      abstract     = {Axon growth enables the rapid wiring of the central nervous
                      system. Understanding this process is a prerequisite to
                      retriggering it under pathological conditions, such as a
                      spinal cord injury, to elicit axon regeneration. The last
                      decades saw progress in understanding the mechanisms
                      underlying axon growth. Most of these studies employed
                      cultured neurons grown on flat surfaces. Only recently
                      studies on axon growth were performed in 3D. In these
                      studies, physiological environments exposed more complex and
                      dynamic aspects of axon development. Here, we describe
                      current views on axon growth and highlight gaps in our
                      knowledge. We discuss how axons interact with the
                      extracellular matrix during development and the role of the
                      growth cone and its cytoskeleton within. Finally, we propose
                      that the time is ripe to study axon growth in a more
                      physiological setting. This will help us uncover the
                      physiologically relevant mechanisms underlying axon growth,
                      and how they can be reactivated to induce axon
                      regeneration.},
      subtyp        = {Review Article},
      keywords     = {Axons: physiology / Nerve Regeneration / Neurons / Central
                      Nervous System / Neurogenesis: physiology / Growth Cones /
                      Axon growth (Other) / Cytoskeleton (Other) / Growth cone
                      (Other) / Neuronal polarisation (Other)},
      cin          = {AG Bradke},
      ddc          = {570},
      cid          = {I:(DE-2719)1013002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35817655},
      doi          = {10.1016/j.semcdb.2022.07.001},
      url          = {https://pub.dzne.de/record/164942},
}