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000164944 037__ $$aDZNE-2022-01348
000164944 041__ $$aEnglish
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000164944 1001_ $$00000-0001-6408-0351$$aDomenighetti, Cloé$$b0
000164944 245__ $$aThe Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.
000164944 260__ $$aNew York, NY$$bWiley$$c2022
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000164944 520__ $$aTwo studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions.To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction.We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1.At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59-0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking-induced modifications of α-synuclein on binding affinity showed findings consistent with this interaction pattern.Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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000164944 650_7 $$2Other$$aHLA
000164944 650_7 $$2Other$$aParkinson's disease
000164944 650_7 $$2Other$$agene-environment interaction
000164944 650_7 $$2Other$$asmoking
000164944 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000164944 650_2 $$2MeSH$$aHLA-DRB1 Chains: genetics
000164944 650_2 $$2MeSH$$aHumans
000164944 650_2 $$2MeSH$$aParkinson Disease: genetics
000164944 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000164944 650_2 $$2MeSH$$aSmoking: genetics
000164944 7001_ $$aDouillard, Venceslas$$b1
000164944 7001_ $$aSugier, Pierre-Emmanuel$$b2
000164944 7001_ $$aSreelatha, Ashwin Ashok Kumar$$b3
000164944 7001_ $$0P:(DE-2719)9000366$$aSchulte, Claudia$$b4$$udzne
000164944 7001_ $$00000-0003-2615-4916$$aGrover, Sandeep$$b5
000164944 7001_ $$00000-0001-8698-3770$$aMay, Patrick$$b6
000164944 7001_ $$00000-0002-1368-9623$$aBobbili, Dheeraj R$$b7
000164944 7001_ $$aRadivojkov-Blagojevic, Milena$$b8
000164944 7001_ $$aLichtner, Peter$$b9
000164944 7001_ $$aSingleton, Andrew B$$b10
000164944 7001_ $$0P:(DE-2719)2812102$$aHernandez, Dena Michelle Godwin$$b11$$udzne
000164944 7001_ $$aEdsall, Connor$$b12
000164944 7001_ $$aGourraud, Pierre-Antoine$$b13
000164944 7001_ $$aMellick, George D$$b14
000164944 7001_ $$aZimprich, Alexander$$b15
000164944 7001_ $$aPirker, Walter$$b16
000164944 7001_ $$aRogaeva, Ekaterina$$b17
000164944 7001_ $$aLang, Anthony E$$b18
000164944 7001_ $$aKoks, Sulev$$b19
000164944 7001_ $$aTaba, Pille$$b20
000164944 7001_ $$aLesage, Suzanne$$b21
000164944 7001_ $$aBrice, Alexis$$b22
000164944 7001_ $$00000-0001-7325-0199$$aCorvol, Jean-Christophe$$b23
000164944 7001_ $$aChartier-Harlin, Marie-Christine$$b24
000164944 7001_ $$00000-0002-5947-0432$$aMutez, Eugénie$$b25
000164944 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b26$$udzne
000164944 7001_ $$aDeutschländer, Angela B$$b27
000164944 7001_ $$aHadjigeorgiou, Georges M$$b28
000164944 7001_ $$aDardiotis, Efthimos$$b29
000164944 7001_ $$aStefanis, Leonidas$$b30
000164944 7001_ $$aSimitsi, Athina Maria$$b31
000164944 7001_ $$00000-0002-0600-6820$$aValente, Enza Maria$$b32
000164944 7001_ $$aPetrucci, Simona$$b33
000164944 7001_ $$aDuga, Stefano$$b34
000164944 7001_ $$aStraniero, Letizia$$b35
000164944 7001_ $$aZecchinelli, Anna$$b36
000164944 7001_ $$aPezzoli, Gianni$$b37
000164944 7001_ $$aBrighina, Laura$$b38
000164944 7001_ $$aFerrarese, Carlo$$b39
000164944 7001_ $$aAnnesi, Grazia$$b40
000164944 7001_ $$aQuattrone, Andrea$$b41
000164944 7001_ $$aGagliardi, Monica$$b42
000164944 7001_ $$aMatsuo, Hirotaka$$b43
000164944 7001_ $$aNakayama, Akiyoshi$$b44
000164944 7001_ $$aHattori, Nobutaka$$b45
000164944 7001_ $$aNishioka, Kenya$$b46
000164944 7001_ $$aChung, Sun Ju$$b47
000164944 7001_ $$aKim, Yun Joong$$b48
000164944 7001_ $$aKolber, Pierre$$b49
000164944 7001_ $$avan de Warrenburg, Bart P C$$b50
000164944 7001_ $$aBloem, Bastiaan R$$b51
000164944 7001_ $$aAasly, Jan$$b52
000164944 7001_ $$00000-0002-6723-6865$$aToft, Mathias$$b53
000164944 7001_ $$aPihlstrøm, Lasse$$b54
000164944 7001_ $$aCorreia Guedes, Leonor$$b55
000164944 7001_ $$00000-0003-3950-5113$$aFerreira, Joaquim J$$b56
000164944 7001_ $$00000-0002-3508-3438$$aBardien, Soraya$$b57
000164944 7001_ $$aCarr, Jonathan$$b58
000164944 7001_ $$00000-0002-3781-0854$$aTolosa, Eduardo$$b59
000164944 7001_ $$00000-0003-3246-6641$$aEzquerra, Mario$$b60
000164944 7001_ $$aPastor, Pau$$b61
000164944 7001_ $$aDiez-Fairen, Monica$$b62
000164944 7001_ $$aWirdefeldt, Karin$$b63
000164944 7001_ $$aPedersen, Nancy L$$b64
000164944 7001_ $$aRan, Caroline$$b65
000164944 7001_ $$aBelin, Andrea C$$b66
000164944 7001_ $$aPuschmann, Andreas$$b67
000164944 7001_ $$aYgland Rödström, Emil$$b68
000164944 7001_ $$aClarke, Carl E$$b69
000164944 7001_ $$aMorrison, Karen E$$b70
000164944 7001_ $$00000-0001-5835-669X$$aTan, Manuela$$b71
000164944 7001_ $$aKraincMD, Dimitri$$b72
000164944 7001_ $$0P:(DE-2719)9000040$$aBurbulla, Lena F$$b73$$udzne
000164944 7001_ $$aFarrer, Matt J$$b74
000164944 7001_ $$0P:(DE-2719)2811170$$aKrüger, Rejko$$b75$$udzne
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000164944 7001_ $$aVince, Nicolas$$b78
000164944 7001_ $$00000-0001-9724-5490$$aElbaz, Alexis$$b79
000164944 7001_ $$aGenetics, Comprehensive Unbiased Risk Factor Assessment for$$b80
000164944 7001_ $$aDisease, Environment in Parkinson's$$b81$$eCollaboration Author
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