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@ARTICLE{Domenighetti:164944,
      author       = {Domenighetti, Cloé and Douillard, Venceslas and Sugier,
                      Pierre-Emmanuel and Sreelatha, Ashwin Ashok Kumar and
                      Schulte, Claudia and Grover, Sandeep and May, Patrick and
                      Bobbili, Dheeraj R and Radivojkov-Blagojevic, Milena and
                      Lichtner, Peter and Singleton, Andrew B and Hernandez, Dena
                      Michelle Godwin and Edsall, Connor and Gourraud,
                      Pierre-Antoine and Mellick, George D and Zimprich, Alexander
                      and Pirker, Walter and Rogaeva, Ekaterina and Lang, Anthony
                      E and Koks, Sulev and Taba, Pille and Lesage, Suzanne and
                      Brice, Alexis and Corvol, Jean-Christophe and
                      Chartier-Harlin, Marie-Christine and Mutez, Eugénie and
                      Brockmann, Kathrin and Deutschländer, Angela B and
                      Hadjigeorgiou, Georges M and Dardiotis, Efthimos and
                      Stefanis, Leonidas and Simitsi, Athina Maria and Valente,
                      Enza Maria and Petrucci, Simona and Duga, Stefano and
                      Straniero, Letizia and Zecchinelli, Anna and Pezzoli, Gianni
                      and Brighina, Laura and Ferrarese, Carlo and Annesi, Grazia
                      and Quattrone, Andrea and Gagliardi, Monica and Matsuo,
                      Hirotaka and Nakayama, Akiyoshi and Hattori, Nobutaka and
                      Nishioka, Kenya and Chung, Sun Ju and Kim, Yun Joong and
                      Kolber, Pierre and van de Warrenburg, Bart P C and Bloem,
                      Bastiaan R and Aasly, Jan and Toft, Mathias and Pihlstrøm,
                      Lasse and Correia Guedes, Leonor and Ferreira, Joaquim J and
                      Bardien, Soraya and Carr, Jonathan and Tolosa, Eduardo and
                      Ezquerra, Mario and Pastor, Pau and Diez-Fairen, Monica and
                      Wirdefeldt, Karin and Pedersen, Nancy L and Ran, Caroline
                      and Belin, Andrea C and Puschmann, Andreas and Ygland
                      Rödström, Emil and Clarke, Carl E and Morrison, Karen E
                      and Tan, Manuela and KraincMD, Dimitri and Burbulla, Lena F
                      and Farrer, Matt J and Krüger, Rejko and Gasser, Thomas and
                      Sharma, Manu and Vince, Nicolas and Elbaz, Alexis and
                      Genetics, Comprehensive Unbiased Risk Factor Assessment for},
      collaboration = {Disease, Environment in Parkinson's},
      title        = {{T}he {I}nteraction between {HLA}-{DRB}1 and {S}moking in
                      {P}arkinson's {D}isease {R}evisited.},
      journal      = {Movement disorders},
      volume       = {37},
      number       = {9},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2022-01348},
      pages        = {1929-1937},
      year         = {2022},
      note         = {CC BY-NC},
      abstract     = {Two studies that examined the interaction between HLA-DRB1
                      and smoking in Parkinson's disease (PD) yielded findings in
                      opposite directions.To perform a large-scale independent
                      replication of the HLA-DRB1 × smoking interaction.We
                      genotyped 182 single nucleotide polymorphism (SNPs)
                      associated with smoking initiation in 12 424 cases and 9480
                      controls to perform a Mendelian randomization (MR) analysis
                      in strata defined by HLA-DRB1.At the amino acid level, a
                      valine at position 11 (V11) in HLA-DRB1 displayed the
                      strongest association with PD. MR showed an inverse
                      association between genetically predicted smoking initiation
                      and PD only in absence of V11 (odds ratio, 0.74, $95\%$
                      confidence interval, 0.59-0.93, PInteraction = 0.028). In
                      silico predictions of the influence of V11 and
                      smoking-induced modifications of α-synuclein on binding
                      affinity showed findings consistent with this interaction
                      pattern.Despite being one of the most robust findings in PD
                      research, the mechanisms underlying the inverse association
                      between smoking and PD remain unknown. Our findings may help
                      better understand this association. © 2022 The Authors.
                      Movement Disorders published by Wiley Periodicals LLC on
                      behalf of International Parkinson and Movement Disorder
                      Society.},
      keywords     = {Genetic Predisposition to Disease / HLA-DRB1 Chains:
                      genetics / Humans / Parkinson Disease: genetics /
                      Polymorphism, Single Nucleotide: genetics / Smoking:
                      genetics / HLA (Other) / Parkinson's disease (Other) /
                      gene-environment interaction (Other) / smoking (Other)},
      cin          = {AG Gasser / AG Burbulla},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)5000074},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9597672},
      pubmed       = {pmid:35810454},
      doi          = {10.1002/mds.29133},
      url          = {https://pub.dzne.de/record/164944},
}