Home > Publications Database > The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited. > print

001     164944
005     20240722121854.0
024 7 _ |a pmc:PMC9597672
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024 7 _ |a 10.1002/mds.29133
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024 7 _ |a pmid:35810454
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024 7 _ |a 0885-3185
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024 7 _ |a 1531-8257
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024 7 _ |a altmetric:130936229
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037 _ _ |a DZNE-2022-01348
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Domenighetti, Cloé
|0 0000-0001-6408-0351
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245 _ _ |a The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.
260 _ _ |a New York, NY
|c 2022
|b Wiley
336 7 _ |a article
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336 7 _ |a ARTICLE
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500 _ _ |a CC BY-NC
520 _ _ |a Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions.To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction.We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1.At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59-0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking-induced modifications of α-synuclein on binding affinity showed findings consistent with this interaction pattern.Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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650 _ 7 |a HLA
|2 Other
650 _ 7 |a Parkinson's disease
|2 Other
650 _ 7 |a gene-environment interaction
|2 Other
650 _ 7 |a smoking
|2 Other
650 _ 2 |a Genetic Predisposition to Disease
|2 MeSH
650 _ 2 |a HLA-DRB1 Chains: genetics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Parkinson Disease: genetics
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide: genetics
|2 MeSH
650 _ 2 |a Smoking: genetics
|2 MeSH
700 1 _ |a Douillard, Venceslas
|b 1
700 1 _ |a Sugier, Pierre-Emmanuel
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700 1 _ |a Sreelatha, Ashwin Ashok Kumar
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700 1 _ |a Schulte, Claudia
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700 1 _ |a Grover, Sandeep
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700 1 _ |a May, Patrick
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700 1 _ |a Bobbili, Dheeraj R
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700 1 _ |a Radivojkov-Blagojevic, Milena
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700 1 _ |a Lichtner, Peter
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700 1 _ |a Singleton, Andrew B
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700 1 _ |a Hernandez, Dena Michelle Godwin
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700 1 _ |a Edsall, Connor
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700 1 _ |a Gourraud, Pierre-Antoine
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700 1 _ |a Mellick, George D
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700 1 _ |a Zimprich, Alexander
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700 1 _ |a Pirker, Walter
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700 1 _ |a Rogaeva, Ekaterina
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700 1 _ |a Lang, Anthony E
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700 1 _ |a Koks, Sulev
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700 1 _ |a Taba, Pille
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700 1 _ |a Lesage, Suzanne
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700 1 _ |a Brice, Alexis
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700 1 _ |a Corvol, Jean-Christophe
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700 1 _ |a Chartier-Harlin, Marie-Christine
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700 1 _ |a Mutez, Eugénie
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700 1 _ |a Brockmann, Kathrin
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700 1 _ |a Deutschländer, Angela B
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700 1 _ |a Hadjigeorgiou, Georges M
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700 1 _ |a Dardiotis, Efthimos
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700 1 _ |a Stefanis, Leonidas
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700 1 _ |a Simitsi, Athina Maria
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700 1 _ |a Valente, Enza Maria
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700 1 _ |a Petrucci, Simona
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700 1 _ |a Duga, Stefano
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700 1 _ |a Straniero, Letizia
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700 1 _ |a Zecchinelli, Anna
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700 1 _ |a Pezzoli, Gianni
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700 1 _ |a Brighina, Laura
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700 1 _ |a Ferrarese, Carlo
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700 1 _ |a Annesi, Grazia
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700 1 _ |a Quattrone, Andrea
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700 1 _ |a Gagliardi, Monica
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700 1 _ |a Matsuo, Hirotaka
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700 1 _ |a Nakayama, Akiyoshi
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700 1 _ |a Hattori, Nobutaka
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700 1 _ |a Nishioka, Kenya
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700 1 _ |a Chung, Sun Ju
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700 1 _ |a Kim, Yun Joong
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700 1 _ |a Kolber, Pierre
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700 1 _ |a van de Warrenburg, Bart P C
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700 1 _ |a Bloem, Bastiaan R
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700 1 _ |a Aasly, Jan
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700 1 _ |a Toft, Mathias
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700 1 _ |a Pihlstrøm, Lasse
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700 1 _ |a Correia Guedes, Leonor
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700 1 _ |a Ferreira, Joaquim J
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700 1 _ |a Bardien, Soraya
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700 1 _ |a Carr, Jonathan
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700 1 _ |a Tolosa, Eduardo
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700 1 _ |a Ezquerra, Mario
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700 1 _ |a Pastor, Pau
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700 1 _ |a Diez-Fairen, Monica
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700 1 _ |a Wirdefeldt, Karin
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700 1 _ |a Pedersen, Nancy L
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700 1 _ |a Ran, Caroline
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700 1 _ |a Belin, Andrea C
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700 1 _ |a Puschmann, Andreas
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700 1 _ |a Ygland Rödström, Emil
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700 1 _ |a Clarke, Carl E
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700 1 _ |a Morrison, Karen E
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700 1 _ |a Tan, Manuela
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700 1 _ |a KraincMD, Dimitri
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700 1 _ |a Burbulla, Lena F
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700 1 _ |a Farrer, Matt J
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700 1 _ |a Krüger, Rejko
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700 1 _ |a Gasser, Thomas
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700 1 _ |a Sharma, Manu
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700 1 _ |a Vince, Nicolas
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700 1 _ |a Elbaz, Alexis
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700 1 _ |a Genetics, Comprehensive Unbiased Risk Factor Assessment for
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700 1 _ |a Disease, Environment in Parkinson's
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773 _ _ |a 10.1002/mds.29133
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