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000164963 037__ $$aDZNE-2022-01367
000164963 041__ $$aEnglish
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000164963 1001_ $$aGeorgakis, Marios K$$b0
000164963 245__ $$aCerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study.
000164963 260__ $$aHoboken, NJ$$bWiley$$c2023
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000164963 520__ $$aIt remains unknown whether the global small vessel disease (SVD) burden predicts post-stroke outcomes.In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonance imaging (MRI)-based SVD markers (lacunes, white matter hyperintensities, microbleeds, perivascular spaces) and explored associations with 6- and 12-month cognitive (battery of 15 neuropsychological tests) and functional (modified Rankin scale) outcomes.A global SVD score (range 0-4) was associated with cognitive impairment; worse performance in executive function, attention, language, and visuospatial ability; and worse functional outcome across a 12-month follow-up. Although the global SVD score did not improve prediction, individual SVD markers, assessed across their severity range, improved the calibration, discrimination, and reclassification of predictive models including demographic, clinical, and other imaging factors.SVD presence and severity are associated with worse cognitive and functional outcomes 12 months after stroke. Assessing SVD severity may aid prognostication for stroke patients.In a multi-center cohort, we explored associations of small vessel disease (SVD) burden with stroke outcomes. SVD burden associates with post-stroke cognitive and functional outcomes. A currently used score of SVD burden does not improve the prediction of poor outcomes. Assessing the severity of SVD lesions adds predictive value beyond known predictors. To add predictive value in assessing SVD in stroke patients, SVD burden scores should integrate lesion severity.
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000164963 650_7 $$2Other$$acerebral small vessel disease
000164963 650_7 $$2Other$$acognitive impairment
000164963 650_7 $$2Other$$afunctional outcome
000164963 650_7 $$2Other$$aprediction
000164963 650_7 $$2Other$$astroke
000164963 650_2 $$2MeSH$$aHumans
000164963 650_2 $$2MeSH$$aProspective Studies
000164963 650_2 $$2MeSH$$aStroke: complications
000164963 650_2 $$2MeSH$$aStroke: pathology
000164963 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: pathology
000164963 650_2 $$2MeSH$$aCognitive Dysfunction: complications
000164963 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000164963 650_2 $$2MeSH$$aCognition
000164963 7001_ $$aFang, Rong$$b1
000164963 7001_ $$0P:(DE-2719)9000062$$aDüring, Marco$$b2
000164963 7001_ $$aWollenweber, Frank A$$b3
000164963 7001_ $$0P:(DE-2719)2811949$$aBode, Felix J$$b4
000164963 7001_ $$0P:(DE-2719)9000778$$aStoesser, Sebastian$$b5
000164963 7001_ $$0P:(DE-2719)9002345$$aKindlein, Christine$$b6$$udzne
000164963 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b7
000164963 7001_ $$0P:(DE-2719)9000189$$aLiman, Thomas G$$b8
000164963 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian H$$b9
000164963 7001_ $$0P:(DE-2719)2811628$$aKerti, Lucia$$b10
000164963 7001_ $$aIkenberg, Benno$$b11
000164963 7001_ $$aBernkopf, Kathleen$$b12
000164963 7001_ $$aPoppert, Holger$$b13
000164963 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b14
000164963 7001_ $$0P:(DE-2719)9000985$$aPerosa, Valentina$$b15
000164963 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b16$$udzne
000164963 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b17
000164963 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b18
000164963 7001_ $$0P:(DE-2719)2810706$$aSpeck, Oliver$$b19
000164963 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b20
000164963 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b21
000164963 7001_ $$0P:(DE-2719)9001112$$aGesierich, Benno$$b22
000164963 7001_ $$aDewenter, Anna$$b23
000164963 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b24
000164963 7001_ $$0P:(DE-2719)2814124$$aWaegemann, Karin$$b25
000164963 7001_ $$0P:(DE-2719)2811292$$aGörtler, Michael$$b26
000164963 7001_ $$aWunderlich, Silke$$b27
000164963 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b28
000164963 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b29
000164963 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor$$b30
000164963 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b31$$eLast author
000164963 7001_ $$aInvestigators, DEMDAS$$b32$$eCollaboration Author
000164963 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12744$$gp. alz.12744$$n4$$p1152 - 1163$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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