TY  - JOUR
AU  - Georgakis, Marios K
AU  - Fang, Rong
AU  - Düring, Marco
AU  - Wollenweber, Frank A
AU  - Bode, Felix J
AU  - Stoesser, Sebastian
AU  - Kindlein, Christine
AU  - Hermann, Peter
AU  - Liman, Thomas G
AU  - Nolte, Christian H
AU  - Kerti, Lucia
AU  - Ikenberg, Benno
AU  - Bernkopf, Kathleen
AU  - Poppert, Holger
AU  - Glanz, Wenzel
AU  - Perosa, Valentina
AU  - Janowitz, Daniel
AU  - Wagner, Michael
AU  - Neumann, Katja
AU  - Speck, Oliver
AU  - Dobisch, Laura
AU  - Düzel, Emrah
AU  - Gesierich, Benno
AU  - Dewenter, Anna
AU  - Spottke, Annika
AU  - Waegemann, Karin
AU  - Görtler, Michael
AU  - Wunderlich, Silke
AU  - Endres, Matthias
AU  - Zerr, Inga
AU  - Petzold, Gabor
AU  - Dichgans, Martin
TI  - Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study.
JO  - Alzheimer's and dementia
VL  - 19
IS  - 4
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2022-01367
SP  - 1152 - 1163
PY  - 2023
N1  - CC BY-NC
AB  - It remains unknown whether the global small vessel disease (SVD) burden predicts post-stroke outcomes.In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonance imaging (MRI)-based SVD markers (lacunes, white matter hyperintensities, microbleeds, perivascular spaces) and explored associations with 6- and 12-month cognitive (battery of 15 neuropsychological tests) and functional (modified Rankin scale) outcomes.A global SVD score (range 0-4) was associated with cognitive impairment; worse performance in executive function, attention, language, and visuospatial ability; and worse functional outcome across a 12-month follow-up. Although the global SVD score did not improve prediction, individual SVD markers, assessed across their severity range, improved the calibration, discrimination, and reclassification of predictive models including demographic, clinical, and other imaging factors.SVD presence and severity are associated with worse cognitive and functional outcomes 12 months after stroke. Assessing SVD severity may aid prognostication for stroke patients.In a multi-center cohort, we explored associations of small vessel disease (SVD) burden with stroke outcomes. SVD burden associates with post-stroke cognitive and functional outcomes. A currently used score of SVD burden does not improve the prediction of poor outcomes. Assessing the severity of SVD lesions adds predictive value beyond known predictors. To add predictive value in assessing SVD in stroke patients, SVD burden scores should integrate lesion severity.
KW  - Humans
KW  - Prospective Studies
KW  - Stroke: complications
KW  - Stroke: pathology
KW  - Cerebral Small Vessel Diseases: pathology
KW  - Cognitive Dysfunction: complications
KW  - Magnetic Resonance Imaging
KW  - Cognition
KW  - cerebral small vessel disease (Other)
KW  - cognitive impairment (Other)
KW  - functional outcome (Other)
KW  - prediction (Other)
KW  - stroke (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35876563
DO  - DOI:10.1002/alz.12744
UR  - https://pub.dzne.de/record/164963
ER  -