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@ARTICLE{Georgakis:164963,
      author       = {Georgakis, Marios K and Fang, Rong and Düring, Marco and
                      Wollenweber, Frank A and Bode, Felix J and Stoesser,
                      Sebastian and Kindlein, Christine and Hermann, Peter and
                      Liman, Thomas G and Nolte, Christian H and Kerti, Lucia and
                      Ikenberg, Benno and Bernkopf, Kathleen and Poppert, Holger
                      and Glanz, Wenzel and Perosa, Valentina and Janowitz, Daniel
                      and Wagner, Michael and Neumann, Katja and Speck, Oliver and
                      Dobisch, Laura and Düzel, Emrah and Gesierich, Benno and
                      Dewenter, Anna and Spottke, Annika and Waegemann, Karin and
                      Görtler, Michael and Wunderlich, Silke and Endres, Matthias
                      and Zerr, Inga and Petzold, Gabor and Dichgans, Martin},
      collaboration = {Investigators, DEMDAS},
      title        = {{C}erebral small vessel disease burden and cognitive and
                      functional outcomes after stroke: {A} multicenter
                      prospective cohort study.},
      journal      = {Alzheimer's and dementia},
      volume       = {19},
      number       = {4},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2022-01367},
      pages        = {1152 - 1163},
      year         = {2023},
      note         = {CC BY-NC},
      abstract     = {It remains unknown whether the global small vessel disease
                      (SVD) burden predicts post-stroke outcomes.In a prospective
                      multicenter study of 666 ischemic and hemorrhagic stroke
                      patients, we quantified magnetic resonance imaging
                      (MRI)-based SVD markers (lacunes, white matter
                      hyperintensities, microbleeds, perivascular spaces) and
                      explored associations with 6- and 12-month cognitive
                      (battery of 15 neuropsychological tests) and functional
                      (modified Rankin scale) outcomes.A global SVD score (range
                      0-4) was associated with cognitive impairment; worse
                      performance in executive function, attention, language, and
                      visuospatial ability; and worse functional outcome across a
                      12-month follow-up. Although the global SVD score did not
                      improve prediction, individual SVD markers, assessed across
                      their severity range, improved the calibration,
                      discrimination, and reclassification of predictive models
                      including demographic, clinical, and other imaging
                      factors.SVD presence and severity are associated with worse
                      cognitive and functional outcomes 12 months after stroke.
                      Assessing SVD severity may aid prognostication for stroke
                      patients.In a multi-center cohort, we explored associations
                      of small vessel disease (SVD) burden with stroke outcomes.
                      SVD burden associates with post-stroke cognitive and
                      functional outcomes. A currently used score of SVD burden
                      does not improve the prediction of poor outcomes. Assessing
                      the severity of SVD lesions adds predictive value beyond
                      known predictors. To add predictive value in assessing SVD
                      in stroke patients, SVD burden scores should integrate
                      lesion severity.},
      keywords     = {Humans / Prospective Studies / Stroke: complications /
                      Stroke: pathology / Cerebral Small Vessel Diseases:
                      pathology / Cognitive Dysfunction: complications / Magnetic
                      Resonance Imaging / Cognition / cerebral small vessel
                      disease (Other) / cognitive impairment (Other) / functional
                      outcome (Other) / prediction (Other) / stroke (Other)},
      cin          = {AG Dichgans / AG Petzold / Patient Studies Bonn / AG Endres
                      / AG Düzel / KAP / AG Wagner / AG Speck / AG Klockgether /
                      AG Levin / AG Zerr},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022 / I:(DE-2719)1013020 /
                      I:(DE-2719)1011101 / I:(DE-2719)1811005 / I:(DE-2719)5000006
                      / I:(DE-2719)1340013 / I:(DE-2719)1011201 /
                      I:(DE-2719)1340009 / I:(DE-2719)1011001 / I:(DE-2719)1111016
                      / I:(DE-2719)1440011-1},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35876563},
      doi          = {10.1002/alz.12744},
      url          = {https://pub.dzne.de/record/164963},
}