%0 Journal Article
%A Demnitz-King, Harriet
%A Gonneaud, Julie
%A Klimecki, Olga M
%A Chocat, Anne
%A Collette, Fabienne
%A Dautricourt, Sophie
%A Jessen, Frank
%A Krolak-Salmon, Pierre
%A Lutz, Antoine
%A Morse, Rachel M
%A Molinuevo, José Luis
%A Poisnel, Géraldine
%A Touron, Edelweiss
%A Wirth, Miranka
%A Walker, Zuzana
%A Chételat, Gaël
%A Marchant, Natalie L
%T Association Between Self-Reflection, Cognition, and Brain Health in Cognitively Unimpaired Older Adults.
%J Neurology
%V 99
%N 13
%@ 0028-3878
%C [S.l.]
%I Ovid
%M DZNE-2022-01387
%P e1422 - e1431
%D 2022
%X Self-reflection (the active evaluation of ones thoughts, feelings and behaviours) can confer protection against adverse health outcomes. Its impact on markers sensitive to Alzheimer's disease (AD), however, is unknown. The primary objective of this cross-sectional study was to examine the association between self-reflection and AD-sensitive markers.This study utilised baseline data from cognitively unimpaired older adults enrolled in the Age-Well clinical trial and older adults with subjective cognitive decline from the SCD-Well clinical trial. In both cohorts, self-reflection was measured via the reflective pondering subscale of the Rumination Response Scale, global cognition assessed via the Preclinical Alzheimer's Cognitive Composite 5, and a modified late-life Lifestyle-for-Brain-Health (LIBRA) index computed to assess health and lifestyle factors. In Age-Well, glucose metabolism and amyloid deposition were quantified in AD-sensitive grey matter regions via FDG- and AV45-PET scans, respectively. Associations between self-reflection and AD-sensitive markers (global cognition, glucose metabolism, and amyloid deposition) were assessed via unadjusted and adjusted regressions. Further, we explored whether associations were independent of health and lifestyle factors. To control for multiple comparisons in Age-Well, false discovery rate corrected p-values (p FDR) are reported.A total of 134 (mean age 69.3 ± 3.8 years, 61.9
%K Aged
%K Alzheimer Disease: metabolism
%K Amyloid beta-Peptides: metabolism
%K Biomarkers: metabolism
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Cognition: physiology
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: metabolism
%K Cross-Sectional Studies
%K Female
%K Glucose: metabolism
%K Humans
%K Magnetic Resonance Imaging
%K Male
%K Positron-Emission Tomography
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Glucose (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35853750
%R 10.1212/WNL.0000000000200951
%U https://pub.dzne.de/record/164983