%0 Journal Article
%A Polcher, Alexandra
%A Wolfsgruber, Steffen
%A Peters, Oliver
%A Frölich, Lutz
%A Wiltfang, Jens
%A Kornhuber, Johannes
%A Hüll, Michael
%A Rüther, Eckart
%A Lewczuk, Piotr
%A Maier, Wolfgang
%A Jessen, Frank
%A Wagner, Michael
%T A Comparison of Operational Definitions for Mild Cognitive Impairment.
%J Journal of Alzheimer's disease
%V 88
%N 4
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DZNE-2022-01391
%P 1663-1678
%D 2022
%Z CC BY-NC: https://creativecommons.org/licenses/by-nc/4.0/
%X Consideration of many tests from different cognitive domains in defining mild cognitive impairment (MCI) is clinical routine, but guidelines for a neuropsychological operationalization of MCI are lacking.Among different operational MCI criteria, to identify those which are best in predicting either conversion to dementia, or a biomarker profile indicative for Alzheimer's disease (AD).Memory-clinic patients without dementia (N = 558; mean age = 66; up to 3 years of follow-up; n = 360 with baseline CSF biomarkers) were included in an observational study using most liberal criteria of cognitive impairment. Four operational definitions of MCI were retrospectively applied: 1) amnestic MCI (word list delayed recall), 2) CERAD total score, 3) comprehensive criteria and 4) base rate corrected CERAD. We compared their accuracy in predicting incident all-cause dementia or AD dementia within three years, or a concurrent CSF Aβ42/tau-ratio indicative of AD.The four definitions overlapped considerably, classified 35-58
%K Aged
%K Alzheimer Disease: psychology
%K Amyloid beta-Peptides
%K Biomarkers
%K Cognitive Dysfunction: etiology
%K Disease Progression
%K Humans
%K Male
%K Neuropsychological Tests
%K Retrospective Studies
%K Alzheimer’s disease (Other)
%K DSM-5 mild NCD (Other)
%K biomarker (Other)
%K cognition (Other)
%K conversion (Other)
%K dementia (Other)
%K diagnosis (Other)
%K mild cognitive impairment (Other)
%K prognosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC9484125
%$ pmid:35811516
%R 10.3233/JAD-215548
%U https://pub.dzne.de/record/164987