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000164987 041__ $$aEnglish
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000164987 1001_ $$0P:(DE-2719)2810925$$aPolcher, Alexandra$$b0$$udzne
000164987 245__ $$aA Comparison of Operational Definitions for Mild Cognitive Impairment.
000164987 260__ $$aAmsterdam$$bIOS Press$$c2022
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000164987 520__ $$aConsideration of many tests from different cognitive domains in defining mild cognitive impairment (MCI) is clinical routine, but guidelines for a neuropsychological operationalization of MCI are lacking.Among different operational MCI criteria, to identify those which are best in predicting either conversion to dementia, or a biomarker profile indicative for Alzheimer's disease (AD).Memory-clinic patients without dementia (N = 558; mean age = 66; up to 3 years of follow-up; n = 360 with baseline CSF biomarkers) were included in an observational study using most liberal criteria of cognitive impairment. Four operational definitions of MCI were retrospectively applied: 1) amnestic MCI (word list delayed recall), 2) CERAD total score, 3) comprehensive criteria and 4) base rate corrected CERAD. We compared their accuracy in predicting incident all-cause dementia or AD dementia within three years, or a concurrent CSF Aβ42/tau-ratio indicative of AD.The four definitions overlapped considerably, classified 35-58% of the original sample as impaired and were associated with markedly increased PPVs regarding incident all-cause dementia (39-46% versus 26% of the original sample), AD dementia and AD biomarker positivity. The base-rate corrected MCI definition had the highest prognostic accuracy.he operational criteria examined seem suitable to specify MCI in memory clinic settings, as they identify subjects at high risk of clinical progression. Depending on the neuropsychological battery in use, one or several of these criteria could help to calibrate the clinical judgment of test results, reduce false-positive decisions, and define risk-enriched groups for clinical trials.
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000164987 650_7 $$2Other$$aAlzheimer’s disease
000164987 650_7 $$2Other$$aDSM-5 mild NCD
000164987 650_7 $$2Other$$abiomarker
000164987 650_7 $$2Other$$acognition
000164987 650_7 $$2Other$$aconversion
000164987 650_7 $$2Other$$adementia
000164987 650_7 $$2Other$$adiagnosis
000164987 650_7 $$2Other$$amild cognitive impairment
000164987 650_7 $$2Other$$aprognosis
000164987 650_2 $$2MeSH$$aAged
000164987 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000164987 650_2 $$2MeSH$$aAmyloid beta-Peptides
000164987 650_2 $$2MeSH$$aBiomarkers
000164987 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000164987 650_2 $$2MeSH$$aDisease Progression
000164987 650_2 $$2MeSH$$aHumans
000164987 650_2 $$2MeSH$$aMale
000164987 650_2 $$2MeSH$$aNeuropsychological Tests
000164987 650_2 $$2MeSH$$aRetrospective Studies
000164987 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b1$$udzne
000164987 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b2$$udzne
000164987 7001_ $$0P:(DE-2719)9001189$$aFrölich, Lutz$$b3$$udzne
000164987 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b4$$udzne
000164987 7001_ $$aKornhuber, Johannes$$b5
000164987 7001_ $$aHüll, Michael$$b6
000164987 7001_ $$0P:(DE-2719)9000273$$aRüther, Eckart$$b7$$udzne
000164987 7001_ $$aLewczuk, Piotr$$b8
000164987 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b9$$udzne
000164987 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b10$$udzne
000164987 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b11$$eLast author$$udzne
000164987 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-215548$$gp. 1 - 16$$n4$$p1663-1678$$tJournal of Alzheimer's disease$$v88$$x1387-2877$$y2022
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