TY  - JOUR
AU  - Polcher, Alexandra
AU  - Wolfsgruber, Steffen
AU  - Peters, Oliver
AU  - Frölich, Lutz
AU  - Wiltfang, Jens
AU  - Kornhuber, Johannes
AU  - Hüll, Michael
AU  - Rüther, Eckart
AU  - Lewczuk, Piotr
AU  - Maier, Wolfgang
AU  - Jessen, Frank
AU  - Wagner, Michael
TI  - A Comparison of Operational Definitions for Mild Cognitive Impairment.
JO  - Journal of Alzheimer's disease
VL  - 88
IS  - 4
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2022-01391
SP  - 1663-1678
PY  - 2022
N1  - CC BY-NC: https://creativecommons.org/licenses/by-nc/4.0/
AB  - Consideration of many tests from different cognitive domains in defining mild cognitive impairment (MCI) is clinical routine, but guidelines for a neuropsychological operationalization of MCI are lacking.Among different operational MCI criteria, to identify those which are best in predicting either conversion to dementia, or a biomarker profile indicative for Alzheimer's disease (AD).Memory-clinic patients without dementia (N = 558; mean age = 66; up to 3 years of follow-up; n = 360 with baseline CSF biomarkers) were included in an observational study using most liberal criteria of cognitive impairment. Four operational definitions of MCI were retrospectively applied: 1) amnestic MCI (word list delayed recall), 2) CERAD total score, 3) comprehensive criteria and 4) base rate corrected CERAD. We compared their accuracy in predicting incident all-cause dementia or AD dementia within three years, or a concurrent CSF Aβ42/tau-ratio indicative of AD.The four definitions overlapped considerably, classified 35-58
KW  - Aged
KW  - Alzheimer Disease: psychology
KW  - Amyloid beta-Peptides
KW  - Biomarkers
KW  - Cognitive Dysfunction: etiology
KW  - Disease Progression
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests
KW  - Retrospective Studies
KW  - Alzheimer’s disease (Other)
KW  - DSM-5 mild NCD (Other)
KW  - biomarker (Other)
KW  - cognition (Other)
KW  - conversion (Other)
KW  - dementia (Other)
KW  - diagnosis (Other)
KW  - mild cognitive impairment (Other)
KW  - prognosis (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9484125
C6  - pmid:35811516
DO  - DOI:10.3233/JAD-215548
UR  - https://pub.dzne.de/record/164987
ER  -