% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kaczmarczyk:165105,
      author       = {Kaczmarczyk, Lech and Schleif, Melvin and Dittrich, Lars
                      and Williams, Rhiannan H and Koderman, Maruša and Bansal,
                      Vikas and Rajput, Ashish and Schulte, Theresa and Jonson,
                      Maria and Krost, Clemens and Testaquadra, Fabio J and Bonn,
                      Stefan and Jackson, Walker Scot},
      title        = {{D}istinct translatome changes in specific neural
                      populations precede electroencephalographic changes in
                      prion-infected mice.},
      journal      = {PLoS pathogens},
      volume       = {18},
      number       = {8},
      issn         = {1553-7366},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DZNE-2022-01414},
      pages        = {e1010747},
      year         = {2022},
      note         = {CC BY: https://creativecommons.org/licenses/by/4.0/},
      abstract     = {Selective vulnerability is an enigmatic feature of
                      neurodegenerative diseases (NDs), whereby a widely expressed
                      protein causes lesions in specific cell types and brain
                      regions. Using the RiboTag method in mice, translational
                      responses of five neural subtypes to acquired prion disease
                      (PrD) were measured. Pre-onset and disease onset timepoints
                      were chosen based on longitudinal electroencephalography
                      (EEG) that revealed a gradual increase in theta power
                      between 10- and 18-weeks after prion injection, resembling a
                      clinical feature of human PrD. At disease onset, marked by
                      significantly increased theta power and histopathological
                      lesions, mice had pronounced translatome changes in all five
                      cell types despite appearing normal. Remarkably, at a
                      pre-onset stage, prior to EEG and neuropathological changes,
                      we found that 1) translatomes of astrocytes indicated
                      reduced synthesis of ribosomal and mitochondrial components,
                      2) glutamatergic neurons showed increased expression of
                      cytoskeletal genes, and 3) GABAergic neurons revealed
                      reduced expression of circadian rhythm genes. These data
                      demonstrate that early translatome responses to
                      neurodegeneration emerge prior to conventional markers of
                      disease and are cell type-specific. Therapeutic strategies
                      may need to target multiple pathways in specific populations
                      of cells, early in disease.},
      keywords     = {Animals / Brain: pathology / Electroencephalography /
                      Humans / Mice / Neurons: metabolism / Prion Diseases:
                      pathology / Prions: metabolism / Prions (NLM Chemicals)},
      cin          = {AG Jackson / AG Heutink 1 / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1013019 / I:(DE-2719)1210002 /
                      I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35960762},
      pmc          = {pmc:PMC9401167},
      doi          = {10.1371/journal.ppat.1010747},
      url          = {https://pub.dzne.de/record/165105},
}