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000165118 1001_ $$aLiebe, Thomas$$b0
000165118 245__ $$aInvestigation of the functional pathogenesis of mild cognitive impairment by localisation‐based locus coeruleus resting‐state fMRI
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000165118 520__ $$aDementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.
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000165118 650_2 $$2MeSH$$aHumans
000165118 650_2 $$2MeSH$$aLocus Coeruleus: diagnostic imaging
000165118 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000165118 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000165118 650_2 $$2MeSH$$aGyrus Cinguli
000165118 650_2 $$2MeSH$$aBrain Stem
000165118 650_7 $$2Other$$aattention
000165118 650_7 $$2Other$$alocus coeruleus
000165118 650_7 $$2Other$$amild cognitive impairment
000165118 650_7 $$2Other$$aresting-state fMRI
000165118 7001_ $$0P:(DE-2719)2811090$$aDordevic, Milos$$b1$$udzne
000165118 7001_ $$aKaufmann, Jörn$$b2
000165118 7001_ $$0P:(DE-2719)9000470$$aAvetisyan, Araks$$b3$$udzne
000165118 7001_ $$aSkalej, Martin$$b4
000165118 7001_ $$0P:(DE-2719)2191623$$aMüller, Notger$$b5$$udzne
000165118 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.26039$$gp. hbm.26039$$n18$$p5630-5642$$tHuman brain mapping$$v43$$x1065-9471$$y2022
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