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@ARTICLE{Liebe:165118,
      author       = {Liebe, Thomas and Dordevic, Milos and Kaufmann, Jörn and
                      Avetisyan, Araks and Skalej, Martin and Müller, Notger},
      title        = {{I}nvestigation of the functional pathogenesis of mild
                      cognitive impairment by localisation‐based locus coeruleus
                      resting‐state f{MRI}},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {18},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2022-01425},
      pages        = {5630-5642},
      year         = {2022},
      note         = {CC BY-NC-ND:
                      https://creativecommons.org/licenses/by-nc-nd/4.0/},
      abstract     = {Dementia as one of the most prevalent diseases urges for a
                      better understanding of the central mechanisms responsible
                      for clinical symptoms, and necessitates improvement of
                      actual diagnostic capabilities. The brainstem nucleus locus
                      coeruleus (LC) is a promising target for early diagnosis
                      because of its early structural alterations and its
                      relationship to the functional disturbances in the patients.
                      In this study, we applied our improved method of
                      localisation-based LC resting-state fMRI to investigate the
                      differences in central sensory signal processing when
                      comparing functional connectivity (fc) of a patient group
                      with mild cognitive impairment (MCI, n = 28) and an
                      age-matched healthy control group (n = 29). MCI and control
                      participants could be differentiated in their
                      Mini-Mental-State-Examination (MMSE) scores (p < .001) and
                      LC intensity ratio (p = .010). In the fMRI, LC fc to
                      anterior cingulate cortex (FDR p < .001) and left anterior
                      insula (FDR p = .012) was elevated, and LC fc to right
                      temporoparietal junction (rTPJ, FDR p = .012) and posterior
                      cingulate cortex (PCC, FDR p = .021) was decreased in the
                      patient group. Importantly, LC to rTPJ connectivity was also
                      positively correlated to MMSE scores in MCI patients (p =
                      .017). Furthermore, we found a hyperactivation of the
                      left-insula salience network in the MCI patients. Our
                      results and our proposed disease model shed new light on the
                      functional pathogenesis of MCI by directing to attentional
                      network disturbances, which could aid new therapeutic
                      strategies and provide a marker for diagnosis and prediction
                      of disease progression.},
      keywords     = {Humans / Locus Coeruleus: diagnostic imaging / Magnetic
                      Resonance Imaging / Cognitive Dysfunction: diagnostic
                      imaging / Gyrus Cinguli / Brain Stem / attention (Other) /
                      locus coeruleus (Other) / mild cognitive impairment (Other)
                      / resting-state fMRI (Other)},
      cin          = {AG Müller},
      ddc          = {610},
      cid          = {I:(DE-2719)1310003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9704796},
      pubmed       = {pmid:36441846},
      doi          = {10.1002/hbm.26039},
      url          = {https://pub.dzne.de/record/165118},
}