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@ARTICLE{Liebe:165242,
      author       = {Liebe, Thomas and Kaufmann, Jörn and Hämmerer, Dorothea
                      and Betts, Matthew and Walter, Martin},
      title        = {{I}n vivo tractography of human locus coeruleus-relation to
                      7{T} resting state f{MRI}, psychological measures and single
                      subject validity.},
      journal      = {Molecular psychiatry},
      volume       = {27},
      number       = {12},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {DZNE-2022-01535},
      pages        = {4984-4993},
      year         = {2022},
      note         = {CC BY: https://creativecommons.org/licenses/by/4.0/},
      abstract     = {The locus coeruleus (LC) in the brainstem as the main
                      regulator of brain noradrenaline gains increasing attention
                      because of its involvement in neurologic and psychiatric
                      diseases and its relevance in general to brain function. In
                      this study, we created a structural connectome of the LC
                      nerve fibers based on in vivo MRI tractography to gain an
                      understanding into LC connectivity and its impact on
                      LC-related psychological measures. We combined our
                      structural results with ultra-high field resting-state
                      functional MRI to learn about the relationship between in
                      vivo LC structural and functional connections. Importantly,
                      we reveal that LC brain fibers are strongly associated with
                      psychological measures of anxiety and alertness indicating
                      that LC-noradrenergic connectivity may have an important
                      role on brain function. Lastly, since we analyzed all our
                      data in subject-specific space, we point out the potential
                      of structural LC connectivity to reveal individual
                      characteristics of LC-noradrenergic function on the
                      single-subject level.},
      keywords     = {Humans / Locus Coeruleus / Magnetic Resonance Imaging:
                      methods / Brain: physiology / Connectome: methods /
                      Attention},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9763100},
      pubmed       = {pmid:36117208},
      doi          = {10.1038/s41380-022-01761-x},
      url          = {https://pub.dzne.de/record/165242},
}