000165278 001__ 165278
000165278 005__ 20230915090615.0
000165278 0247_ $$2doi$$a10.1016/j.eclinm.2022.101651
000165278 0247_ $$2pmid$$apmid:36133318
000165278 0247_ $$2pmc$$apmc:PMC9482331
000165278 0247_ $$2altmetric$$aaltmetric:136116940
000165278 037__ $$aDZNE-2022-01571
000165278 041__ $$aEnglish
000165278 082__ $$a610
000165278 1001_ $$aHartung, Tim J$$b0
000165278 245__ $$aFatigue and cognitive impairment after COVID-19: A prospective multicentre study.
000165278 260__ $$aAmsterdam$$bElsevier$$c2022
000165278 3367_ $$2DRIVER$$aarticle
000165278 3367_ $$2DataCite$$aOutput Types/Journal article
000165278 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1665568479_29940
000165278 3367_ $$2BibTeX$$aARTICLE
000165278 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000165278 3367_ $$00$$2EndNote$$aJournal Article
000165278 500__ $$aCC BY: https://creativecommons.org/licenses/by/4.0/
000165278 520__ $$aReliable estimates of frequency, severity and associated factors of both fatigue and cognitive impairment after COVID-19 are needed. Also, it is not clear whether the two are distinct sequelae of COVID-19 or part of the same syndrome.'In this prospective multicentre study, frequency of post-COVID fatigue and cognitive impairment were assessed in n = 969 patients (535 [55%] female) ≥6 months after SARS-CoV-2 infection with the FACIT-Fatigue scale (cut-off ≤30) and Montreal Cognitive Assessment (≤25 mild, ≤17 moderate impairment) between November 15, 2020 and September 29, 2021 at University Medical Center Schleswig-Holstein, Campus Kiel and University Hospital Würzburg in Germany. 969 matched non-COVID controls were drawn from a pre-pandemic, randomised, Germany-wide population survey which also included the FACIT-Fatigue scale. Associated sociodemographic, comorbid, clinical, psychosocial factors and laboratory markers were identified with univariate and multivariable linear regression models.On average 9 months after infection, 19% of patients had clinically relevant fatigue, compared to 8% of matched non-COVID controls (p < 0.001). Factors associated with fatigue were female gender, younger age, history of depression and the number of acute COVID symptoms. Among acute COVID symptoms, altered consciousness, dizziness and myalgia were most strongly associated with long-term fatigue. Moreover, 26% of patients had mild and 1% had moderate cognitive impairment. Factors associated with cognitive impairment were older age, male gender, shorter education and a history of neuropsychiatric disease. There was no significant correlation between fatigue and cognitive impairment and only 5% of patients suffered from both conditions.Fatigue and cognitive impairment are two common, but distinct sequelae of COVID-19 with potentially separate pathophysiological pathways.German Federal Ministry of Education and Research (BMBF).
000165278 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000165278 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000165278 650_7 $$2Other$$aCI, confidence interval
000165278 650_7 $$2Other$$aCOVID-19
000165278 650_7 $$2Other$$aCOVID-19, Coronavirus Disease 2019
000165278 650_7 $$2Other$$aCRP, C-reactive protein
000165278 650_7 $$2Other$$aCSF, cerebrospinal fluid
000165278 650_7 $$2Other$$aCognitive dysfunction
000165278 650_7 $$2Other$$aFatigue
000165278 650_7 $$2Other$$aGAD-7, 7-item anxiety screening questionnaire
000165278 650_7 $$2Other$$aMoCA, Montreal Cognitive Assessment
000165278 650_7 $$2Other$$aNAPKON, National Pandemic Cohort Network
000165278 650_7 $$2Other$$aPCR, polymerase chain reaction
000165278 650_7 $$2Other$$aPHQ-8, 8-item depression module of the Patient Health Questionnaire
000165278 650_7 $$2Other$$aPSQI, Pittsburgh Sleep Quality Index
000165278 650_7 $$2Other$$aPost-acute COVID-19 syndrome
000165278 650_7 $$2Other$$aSARS-CoV-2
000165278 650_7 $$2Other$$aSARS-CoV-2, Severe Acute Respiratory Distress Syndrome caused by Corona Virus 2
000165278 650_7 $$2Other$$aVIF, variance inflation factor
000165278 7001_ $$aNeumann, Christian$$b1
000165278 7001_ $$aBahmer, Thomas$$b2
000165278 7001_ $$aChaplinskaya-Sobol, Irina$$b3
000165278 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b4$$udzne
000165278 7001_ $$aGeritz, Johanna$$b5
000165278 7001_ $$aHaeusler, Karl Georg$$b6
000165278 7001_ $$aHeuschmann, Peter U$$b7
000165278 7001_ $$aHildesheim, Hanna$$b8
000165278 7001_ $$aHinz, Andreas$$b9
000165278 7001_ $$aHopff, Sina$$b10
000165278 7001_ $$aHorn, Anna$$b11
000165278 7001_ $$aKrawczak, Michael$$b12
000165278 7001_ $$aKrist, Lilian$$b13
000165278 7001_ $$aKudelka, Jennifer$$b14
000165278 7001_ $$aLieb, Wolfgang$$b15
000165278 7001_ $$0P:(DE-2719)2501881$$aMaetzler, Corina$$b16$$udzne
000165278 7001_ $$aMehnert-Theuerkauf, Anja$$b17
000165278 7001_ $$aMontellano, Felipe A$$b18
000165278 7001_ $$aMorbach, Caroline$$b19
000165278 7001_ $$aSchmidt, Sein$$b20
000165278 7001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefan$$b21$$udzne
000165278 7001_ $$aSteigerwald, Flo$$b22
000165278 7001_ $$aStörk, Stefan$$b23
000165278 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b24$$udzne
000165278 7001_ $$0P:(DE-2719)9001141$$aFinke, Carsten$$b25$$udzne
000165278 773__ $$0PERI:(DE-600)2946413-4$$a10.1016/j.eclinm.2022.101651$$gVol. 53, p. 101651 -$$p101651$$tEClinicalMedicine$$v53$$x2589-5370$$y2022
000165278 8564_ $$uhttps://pub.dzne.de/record/165278/files/DZNE-2022-01571.pdf$$yOpenAccess
000165278 8564_ $$uhttps://pub.dzne.de/record/165278/files/DZNE-2022-01571.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000165278 909CO $$ooai:pub.dzne.de:165278$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000165278 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811033$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000165278 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2501881$$aExternal Institute$$b16$$kExtern
000165278 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2812631$$aExternal Institute$$b21$$kExtern
000165278 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810915$$aExternal Institute$$b24$$kExtern
000165278 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001141$$aExternal Institute$$b25$$kExtern
000165278 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000165278 9141_ $$y2022
000165278 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000165278 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000165278 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-08-31
000165278 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-08-31
000165278 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bECLINICALMEDICINE : 2021$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-01-26T13:10:03Z
000165278 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-01-26T13:10:03Z
000165278 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-01-26T13:10:03Z
000165278 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-10
000165278 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bECLINICALMEDICINE : 2021$$d2022-11-10
000165278 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lCoordinator of Clinical Research$$x0
000165278 980__ $$ajournal
000165278 980__ $$aVDB
000165278 980__ $$aUNRESTRICTED
000165278 980__ $$aI:(DE-2719)1811005
000165278 9801_ $$aFullTexts