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000165292 1001_ $$0P:(DE-2719)9000495$$aBoettcher, Adriana$$b0$$eFirst author$$udzne
000165292 245__ $$aMusical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.
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000165292 520__ $$aRegular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (n = 70) were compared to controls without a history of musical instrument playing (n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.
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000165292 650_7 $$2Other$$abrain aging
000165292 650_7 $$2Other$$abrain plasticity
000165292 650_7 $$2Other$$acognitive reserve
000165292 650_7 $$2Other$$ainstrument playing
000165292 650_7 $$2Other$$aprevention
000165292 650_7 $$2Other$$aresilience
000165292 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
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000165292 7001_ $$aHaynes, John Dylan$$b14
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000165292 7001_ $$aScheffler, Klaus$$b27
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000165292 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b29$$udzne
000165292 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan J$$b30$$udzne
000165292 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b31$$udzne
000165292 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b32$$udzne
000165292 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b33$$udzne
000165292 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b34$$udzne
000165292 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b35$$udzne
000165292 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b36$$udzne
000165292 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b37$$udzne
000165292 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b38$$udzne
000165292 7001_ $$0P:(DE-2719)2814122$$aWirth, Miranka$$b39$$eLast author$$udzne
000165292 773__ $$0PERI:(DE-600)2563826-9$$a10.3389/fpsyg.2022.945709$$gVol. 13, p. 945709$$p945709$$tFrontiers in psychology$$v13$$x1664-1078$$y2022
000165292 7870_ $$0DZNE-2021-01299$$aBoettcher, Adriana et.al.$$d2021$$iRelatedTo$$r$$tLifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults
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