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@ARTICLE{Boettcher:165292,
      author       = {Boettcher, Adriana and Zarucha, Alexis and Koebe, Theresa
                      and Gaubert, Malo and Höppner, Angela and Altenstein,
                      Slawek and Bartels, Claudia and Bürger, Katharina and
                      Dechent, Peter and Dobisch, Laura and Ewers, Michael and
                      Fliessbach, Klaus and Freiesleben, Silka Dawn and Frommann,
                      Ingo and Haynes, John Dylan and Janowitz, Daniel and
                      Kilimann, Ingo and Kleineidam, Luca and Laske, Christoph and
                      Maier, Franziska and Metzger, Coraline and Munk, Matthias H
                      J and Perneczky, Robert and Peters, Oliver and Priller,
                      Josef and Rauchmann, Boris-Stephan and Roy, Nina and
                      Scheffler, Klaus and Schneider, Anja and Spottke, Annika and
                      Teipel, Stefan J and Wiltfang, Jens and Wolfsgruber, Steffen
                      and Yakupov, Renat and Düzel, Emrah and Jessen, Frank and
                      Röske, Sandra and Wagner, Michael and Kempermann, Gerd and
                      Wirth, Miranka},
      title        = {{M}usical {A}ctivity {D}uring {L}ife {I}s {A}ssociated
                      {W}ith {M}ulti-{D}omain {C}ognitive and {B}rain {B}enefits
                      in {O}lder {A}dults.},
      journal      = {Frontiers in psychology},
      volume       = {13},
      issn         = {1664-1078},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2022-01585},
      pages        = {945709},
      year         = {2022},
      note         = {CC BY: https://creativecommons.org/licenses/by/4.0/},
      abstract     = {Regular musical activity as a complex multimodal lifestyle
                      activity is proposed to be protective against age-related
                      cognitive decline and Alzheimer's disease. This
                      cross-sectional study investigated the association and
                      interplay between musical instrument playing during life,
                      multi-domain cognitive abilities and brain morphology in
                      older adults (OA) from the DZNE-Longitudinal Cognitive
                      Impairment and Dementia Study (DELCODE) study. Participants
                      reporting having played a musical instrument across three
                      life periods (n = 70) were compared to controls without a
                      history of musical instrument playing (n = 70), well-matched
                      for reserve proxies of education, intelligence,
                      socioeconomic status and physical activity. Participants
                      with musical activity outperformed controls in global
                      cognition, working memory, executive functions, language,
                      and visuospatial abilities, with no effects seen for
                      learning and memory. The musically active group had greater
                      gray matter volume in the somatosensory area, but did not
                      differ from controls in higher-order frontal, temporal, or
                      hippocampal volumes. However, the association between gray
                      matter volume in distributed frontal-to-temporal regions and
                      cognitive abilities was enhanced in participants with
                      musical activity compared to controls. We show that playing
                      a musical instrument during life relates to better late-life
                      cognitive abilities and greater brain capacities in OA.
                      Musical activity may serve as a multimodal enrichment
                      strategy that could help preserve cognitive and brain health
                      in late life. Longitudinal and interventional studies are
                      needed to support this notion.},
      keywords     = {brain aging (Other) / brain plasticity (Other) / cognitive
                      reserve (Other) / instrument playing (Other) / prevention
                      (Other) / resilience (Other)},
      cin          = {AG Wirth / AG Donix / Central Personnel and Resources / AG
                      Endres / AG Dichgans / AG Simons / Patient Studies Bonn / AG
                      Wagner / AG Gasser / AG Priller / Clinical Research Platform
                      (CRP) / AG Schneider / AG Düzel / AG Klockgether / AG
                      Teipel / AG Wiltfang / AG Jessen / AG Kempermann / Delcode},
      ddc          = {150},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1710008 /
                      I:(DE-2719)1730002 / I:(DE-2719)1811005 / I:(DE-2719)5000022
                      / I:(DE-2719)1110008 / I:(DE-2719)1011101 /
                      I:(DE-2719)1011201 / I:(DE-2719)1210000 / I:(DE-2719)5000007
                      / I:(DE-2719)1011401 / I:(DE-2719)1011305 /
                      I:(DE-2719)5000006 / I:(DE-2719)1011001 / I:(DE-2719)1510100
                      / I:(DE-2719)1410006 / I:(DE-2719)1011102 /
                      I:(DE-2719)1710001 / I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 351 -
                      Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36092026},
      pmc          = {pmc:PMC9454948},
      doi          = {10.3389/fpsyg.2022.945709},
      url          = {https://pub.dzne.de/record/165292},
}