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000165349 037__ $$aDZNE-2022-01626
000165349 041__ $$aEnglish
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000165349 1001_ $$0P:(DE-2719)2811527$$aWischhof, Lena$$b0$$eFirst author
000165349 245__ $$aBCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
000165349 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2022
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000165349 520__ $$aMammalian SWI/SNF/BAF chromatin remodeling complexes influence cell lineage determination. While the contribution of these complexes to neural progenitor cell (NPC) proliferation and differentiation has been reported, little is known about the transcriptional profiles that determine neurogenesis or gliogenesis. Here, we report that BCL7A is a modulator of the SWI/SNF/BAF complex that stimulates the genome-wide occupancy of the ATPase subunit BRG1. We demonstrate that BCL7A is dispensable for SWI/SNF/BAF complex integrity, whereas it is essential to regulate Notch/Wnt pathway signaling and mitochondrial bioenergetics in differentiating NPCs. Pharmacological stimulation of Wnt signaling restores mitochondrial respiration and attenuates the defective neurogenic patterns observed in NPCs lacking BCL7A. Consistently, treatment with an enhancer of mitochondrial biogenesis, pioglitazone, partially restores mitochondrial respiration and stimulates neuronal differentiation of BCL7A-deficient NPCs. Using conditional BCL7A knockout mice, we reveal that BCL7A expression in NPCs and postmitotic neurons is required for neuronal plasticity and supports behavioral and cognitive performance. Together, our findings define the specific contribution of BCL7A-containing SWI/SNF/BAF complexes to mitochondria-driven NPC commitment, thereby providing a better understanding of the cell-intrinsic transcriptional processes that connect metabolism, neuronal morphogenesis, and cognitive flexibility.
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000165349 650_7 $$2Other$$aBCL7A
000165349 650_7 $$2Other$$aSWI/SNF/BAF complex
000165349 650_7 $$2Other$$acognitive function
000165349 650_7 $$2Other$$amitochondrial OXPHOS
000165349 650_7 $$2Other$$aneural progenitor cells (NPCs)
000165349 650_2 $$2MeSH$$aAnimals
000165349 650_2 $$2MeSH$$aMice
000165349 650_2 $$2MeSH$$aAdenosine Triphosphatases: metabolism
000165349 650_2 $$2MeSH$$aChromatin Assembly and Disassembly
000165349 650_2 $$2MeSH$$aEnergy Metabolism
000165349 650_2 $$2MeSH$$aMitochondria: metabolism
000165349 650_2 $$2MeSH$$aTranscription Factors: genetics
000165349 650_2 $$2MeSH$$aTranscription Factors: metabolism
000165349 650_2 $$2MeSH$$aMicrofilament Proteins: metabolism
000165349 650_2 $$2MeSH$$aNeural Stem Cells: cytology
000165349 650_2 $$2MeSH$$aCell Differentiation
000165349 693__ $$0EXP:(DE-2719)PRECISE-20190321$$5EXP:(DE-2719)PRECISE-20190321$$ePlatform for Single Cell Genomics and Epigenomics at DZNE  University of Bonn$$x0
000165349 7001_ $$0P:(DE-2719)2814197$$aLee, Hang-mao$$b1
000165349 7001_ $$0P:(DE-2719)9002478$$aTutas, Janine$$b2$$udzne
000165349 7001_ $$0P:(DE-2719)2812861$$aOverkott, Clemens$$b3
000165349 7001_ $$0P:(DE-2719)9001618$$aTedt, Eileen$$b4
000165349 7001_ $$0P:(DE-2719)2810452$$aStork, Miriam$$b5
000165349 7001_ $$0P:(DE-2719)9000249$$aPeitz, Michael$$b6
000165349 7001_ $$0P:(DE-2719)9000037$$aBrüstle, Oliver$$b7
000165349 7001_ $$0P:(DE-2719)9000845$$aUlas, Thomas$$b8
000165349 7001_ $$0P:(DE-2719)2812735$$aHändler, Kristian$$b9
000165349 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b10
000165349 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b11
000165349 7001_ $$0P:(DE-2719)2010732$$aNicotera, Pierluigi$$b12
000165349 7001_ $$0P:(DE-2719)2811779$$aSalomoni, Paolo$$b13
000165349 7001_ $$0P:(DE-2719)2158358$$aBano, Daniele$$b14$$eLast author
000165349 773__ $$0PERI:(DE-600)1467419-1$$a10.15252/embj.2022110595$$n23$$pe110595$$tThe EMBO journal$$v41$$x0261-4189$$y2022
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