guest ::
| Home > Publications Database > Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse. > print |
| Home > Publications Database > Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse. > print |
| 001 | 165350 | ||
| 005 | 20230915090618.0 | ||
| 024 | 7 | _ | |a pmc:PMC9670194 |2 pmc |
| 024 | 7 | _ | |a 10.15252/embj.2022110963 |2 doi |
| 024 | 7 | _ | |a pmid:36217825 |2 pmid |
| 024 | 7 | _ | |a 0261-4189 |2 ISSN |
| 024 | 7 | _ | |a 1460-2075 |2 ISSN |
| 024 | 7 | _ | |a altmetric:137002388 |2 altmetric |
| 037 | _ | _ | |a DZNE-2022-01627 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Overhoff, Melina |0 0000-0002-4208-8632 |b 0 |
| 245 | _ | _ | |a Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2022 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1671620400_26523 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Autophagy provides nutrients during starvation and eliminates detrimental cellular components. However, accumulating evidence indicates that autophagy is not merely a housekeeping process. Here, by combining mouse models of neuron-specific ATG5 deficiency in either excitatory or inhibitory neurons with quantitative proteomics, high-content microscopy, and live-imaging approaches, we show that autophagy protein ATG5 functions in neurons to regulate cAMP-dependent protein kinase A (PKA)-mediated phosphorylation of a synapse-confined proteome. This function of ATG5 is independent of bulk turnover of synaptic proteins and requires the targeting of PKA inhibitory R1 subunits to autophagosomes. Neuronal loss of ATG5 causes synaptic accumulation of PKA-R1, which sequesters the PKA catalytic subunit and diminishes cAMP/PKA-dependent phosphorylation of postsynaptic cytoskeletal proteins that mediate AMPAR trafficking. Furthermore, ATG5 deletion in glutamatergic neurons augments AMPAR-dependent excitatory neurotransmission and causes the appearance of spontaneous recurrent seizures in mice. Our findings identify a novel role of autophagy in regulating PKA signaling at glutamatergic synapses and suggest the PKA as a target for restoration of synaptic function in neurodegenerative conditions with autophagy dysfunction. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a PKA |2 Other |
| 650 | _ | 7 | |a autophagy |2 Other |
| 650 | _ | 7 | |a brain |2 Other |
| 650 | _ | 7 | |a phosphorylation |2 Other |
| 650 | _ | 7 | |a synapse |2 Other |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Synapses: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cyclic AMP-Dependent Protein Kinases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction |2 MeSH |
| 650 | _ | 2 | |a Autophagy |2 MeSH |
| 700 | 1 | _ | |a Tellkamp, Frederik |0 0000-0002-0473-7320 |b 1 |
| 700 | 1 | _ | |a Hess, Simon |0 0000-0001-6085-5156 |b 2 |
| 700 | 1 | _ | |a Tolve, Marianna |0 0000-0002-0893-2967 |b 3 |
| 700 | 1 | _ | |a Tutas, Janine |b 4 |
| 700 | 1 | _ | |a Faerfers, Marcel |b 5 |
| 700 | 1 | _ | |a Ickert, Lotte |b 6 |
| 700 | 1 | _ | |a Mohammadi, Milad |0 0000-0003-1755-108X |b 7 |
| 700 | 1 | _ | |a De Bruyckere, Elodie |b 8 |
| 700 | 1 | _ | |a Kallergi, Emmanouela |b 9 |
| 700 | 1 | _ | |a Delle Vedove, Andrea |0 0000-0003-4771-9808 |b 10 |
| 700 | 1 | _ | |a Nikoletopoulou, Vassiliki |b 11 |
| 700 | 1 | _ | |a Wirth, Brunhilde |0 0000-0003-4051-5191 |b 12 |
| 700 | 1 | _ | |a Isensee, Joerg |b 13 |
| 700 | 1 | _ | |a Hucho, Tim |0 0000-0002-4147-9308 |b 14 |
| 700 | 1 | _ | |a Puchkov, Dmytro |0 0000-0001-8341-4847 |b 15 |
| 700 | 1 | _ | |a Isbrandt, Dirk |0 P:(DE-2719)2810976 |b 16 |u dzne |
| 700 | 1 | _ | |a Krueger, Marcus |b 17 |
| 700 | 1 | _ | |a Kloppenburg, Peter |0 0000-0002-4554-404X |b 18 |
| 700 | 1 | _ | |a Kononenko, Natalia L |0 0000-0002-3425-6659 |b 19 |
| 773 | _ | _ | |a 10.15252/embj.2022110963 |0 PERI:(DE-600)1467419-1 |n 22 |p e110963 |t The EMBO journal |v 41 |y 2022 |x 0261-4189 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/165350/files/DZNE-2022-01627.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/165350/files/DZNE-2022-01627.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:165350 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 16 |6 P:(DE-2719)2810976 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-30 |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 |0 LIC:(DE-HGF)CCBYNCND4 |2 HGFVOC |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2021-01-30 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-30 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EMBO J : 2021 |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-12 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-12 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-12 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b EMBO J : 2021 |d 2022-11-12 |
| 920 | 1 | _ | |0 I:(DE-2719)1011003 |k AG Isbrandt |l Experimental Neurophysiology |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1011003 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|