% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hengel:165522,
      author       = {Hengel, Holger and Martus, Peter and Faber, Jennifer and
                      Giunit, Paola and Garcia-Moreno, Hector and Solanky, Nita
                      and Klockgether, Thomas and Reetz, Kathrin and van de
                      Warrenburg, Bart P and Santana, Magda M and Silva, Patrick
                      and Cunha, Maria Ines and de Almeida, Luís Pereira and
                      Timmann, Dagmar and Infante, Jon and de Vries, Jeroen and
                      Lima, Manuela and Pires, Paula and Bushara, Khalaf and
                      Jacobi, Heike and Onyike, Chiadi and Schmahmann, Jeremy D
                      and Hübener-Schmid, Jeannette and Synofzik, Matthis and
                      Schöls, Ludger},
      collaboration = {Initiative, European Spinocerebellar Ataxia
                      Type-3/Machado-Joseph Disease},
      title        = {{T}he frequency of non-motor symptoms in {SCA}3 and their
                      association with disease severity and lifestyle factors.},
      journal      = {Journal of neurology},
      volume       = {270},
      number       = {2},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DZNE-2022-01668},
      pages        = {944-952},
      year         = {2023},
      note         = {ISSN 1432-1459 not unique: **2 hits**.},
      abstract     = {Non-motor symptoms (NMS) are a substantial burden for
                      patients with SCA3. There are limited data on their
                      frequency, and their relation with disease severity and
                      activities of daily living is not clear. In addition,
                      lifestyle may either influence or be affected by the
                      occurrence of NMS.To characterize NMS in SCA3 and
                      investigate possible associations with disease severity and
                      lifestyle factors.In a prospective cohort study, we
                      performed a cross-sectional analysis of NMS in 227 SCA3
                      patients, 42 pre-ataxic mutation carriers, and 112 controls
                      and tested for associations with SARA score, activities of
                      daily living, and the lifestyle factors alcohol consumption,
                      smoking and physical activity.Sleep disturbance, restless
                      legs syndrome, mild cognitive impairment, depression,
                      bladder dysfunction and pallhypesthesia were frequent among
                      SCA3 patients, while mainly absent in pre-ataxic mutation
                      carriers. Except for restless legs syndrome, NMS correlated
                      significantly with disease severity and activities of daily
                      living. Alcohol abstinence was associated with bladder
                      dysfunction. Patients with higher physical activity showed
                      less cognitive impairment and fewer depressive symptoms, but
                      these differences were not significant.This study revealed a
                      clear association between disease severity and NMS, likely
                      driven by the progression of the widespread
                      neurodegenerative process. Associations between lifestyle
                      and NMS can probably be attributed to the influence of NMS
                      on lifestyle.},
      keywords     = {Humans / Restless Legs Syndrome: epidemiology / Prospective
                      Studies / Cross-Sectional Studies / Activities of Daily
                      Living / Patient Acuity / Life Style / Lifestyle (Other) /
                      Non-motor symptoms (Other) / Physical activity (Other) /
                      SCA3 (Other)},
      cin          = {AG Schöls / AG Gasser 1 / Patient studies, Bonn / AG
                      Klockgether},
      ddc          = {610},
      cid          = {I:(DE-2719)5000005 / I:(DE-2719)1210000 /
                      I:(DE-2719)1011101 / I:(DE-2719)1011001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9886646},
      pubmed       = {pmid:36324033},
      doi          = {10.1007/s00415-022-11441-z},
      url          = {https://pub.dzne.de/record/165522},
}