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000165562 037__ $$aDZNE-2022-01704
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000165562 1001_ $$aWhiteside, David J$$b0
000165562 245__ $$aTemporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.
000165562 260__ $$aHoboken, NJ$$bWiley$$c2023
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000165562 520__ $$aWe tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD).For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression.We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion.We investigated brain network predictors of dementia symptom onset Frontotemporal dementia results in characteristic dynamic network patterns Alterations in network dynamics are associated with neuropsychological impairment Network dynamic changes predict symptomatic conversion in presymptomatic carriers Network dynamic changes are associated with longitudinal cognitive decline.
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000165562 650_7 $$2Other$$adisease progression
000165562 650_7 $$2Other$$afrontotemporal dementia
000165562 650_7 $$2Other$$afunctional magnetic resonance imaging (fMRI)
000165562 650_7 $$2Other$$anetwork dynamics
000165562 650_7 $$2Other$$apresymptomatic
000165562 650_2 $$2MeSH$$aHumans
000165562 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnosis
000165562 650_2 $$2MeSH$$aMutation: genetics
000165562 650_2 $$2MeSH$$aBrain
000165562 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000165562 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000165562 7001_ $$aMalpetti, Maura$$b1
000165562 7001_ $$aJones, P Simon$$b2
000165562 7001_ $$aGhosh, Boyd C P$$b3
000165562 7001_ $$aCoyle-Gilchrist, Ian$$b4
000165562 7001_ $$avan Swieten, John C$$b5
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000165562 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12824$$gp. alz.12824$$n5$$p1947-1962$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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