TY  - JOUR
AU  - Whiteside, David J
AU  - Malpetti, Maura
AU  - Jones, P Simon
AU  - Ghosh, Boyd C P
AU  - Coyle-Gilchrist, Ian
AU  - van Swieten, John C
AU  - Seelaar, Harro
AU  - Jiskoot, Lize
AU  - Borroni, Barbara
AU  - Sanchez-Valle, Raquel
AU  - Moreno, Fermin
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Synofzik, Matthis
AU  - Galimberti, Daniela
AU  - Masellis, Mario
AU  - Tartaglia, Maria Carmela
AU  - Finger, Elizabeth
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Tagliavini, Fabrizio
AU  - Butler, Chris R
AU  - Santana, Isabel
AU  - Ber, Isabelle Le
AU  - Gerhard, Alexander
AU  - Ducharme, Simon
AU  - Levin, Johannes
AU  - Danek, Adrian
AU  - Otto, Markus
AU  - Sorbi, Sandro
AU  - Pasquier, Florence
AU  - Bouzigues, Arabella
AU  - Russell, Lucy L
AU  - Rohrer, Jonathan D
AU  - Rowe, James B
AU  - Rittman, Timothy
TI  - Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.
JO  - Alzheimer's and dementia
VL  - 19
IS  - 5
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2022-01704
SP  - 1947-1962
PY  - 2023
AB  - We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD).For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression.We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion.We investigated brain network predictors of dementia symptom onset Frontotemporal dementia results in characteristic dynamic network patterns Alterations in network dynamics are associated with neuropsychological impairment Network dynamic changes predict symptomatic conversion in presymptomatic carriers Network dynamic changes are associated with longitudinal cognitive decline.
KW  - Humans
KW  - Frontotemporal Dementia: diagnosis
KW  - Mutation: genetics
KW  - Brain
KW  - Cognitive Dysfunction: genetics
KW  - Magnetic Resonance Imaging
KW  - disease progression (Other)
KW  - frontotemporal dementia (Other)
KW  - functional magnetic resonance imaging (fMRI) (Other)
KW  - network dynamics (Other)
KW  - presymptomatic (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC7614527
C6  - pmid:36377606
DO  - DOI:10.1002/alz.12824
UR  - https://pub.dzne.de/record/165562
ER  -