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@ARTICLE{Whiteside:165562,
author = {Whiteside, David J and Malpetti, Maura and Jones, P Simon
and Ghosh, Boyd C P and Coyle-Gilchrist, Ian and van
Swieten, John C and Seelaar, Harro and Jiskoot, Lize and
Borroni, Barbara and Sanchez-Valle, Raquel and Moreno,
Fermin and Laforce, Robert and Graff, Caroline and Synofzik,
Matthis and Galimberti, Daniela and Masellis, Mario and
Tartaglia, Maria Carmela and Finger, Elizabeth and
Vandenberghe, Rik and de Mendonça, Alexandre and
Tagliavini, Fabrizio and Butler, Chris R and Santana, Isabel
and Ber, Isabelle Le and Gerhard, Alexander and Ducharme,
Simon and Levin, Johannes and Danek, Adrian and Otto, Markus
and Sorbi, Sandro and Pasquier, Florence and Bouzigues,
Arabella and Russell, Lucy L and Rohrer, Jonathan D and
Rowe, James B and Rittman, Timothy},
collaboration = {consortium, GENFI},
othercontributors = {Esteve, Aitana Sogorb and Nelson, Annabel and Bouzigues,
Arabella and Heller, Carolin and Greaves, Caroline V and
Cash, David and Thomas, David L and Todd, Emily and
Benotmane, Hanya and Zetterberg, Henrik and Swift, Imogen J
and Nicholas, Jennifer and Samra, Kiran and Russell, Lucy L
and Bocchetta, Martina and Shafei, Rachelle and Convery,
Rhian S and Timberlake, Carolyn and Cope, Thomas and
Rittman, Timothy and Benussi, Alberto and Premi, Enrico and
Gasparotti, Roberto and Archetti, Silvana and Gazzina,
Stefano and Cantoni, Valentina and Arighi, Andrea and
Fenoglio, Chiara and Scarpini, Elio and Fumagalli, Giorgio
and Borracci, Vittoria and Rossi, Giacomina and Giaccone,
Giorgio and Di Fede, Giuseppe and Caroppo, Paola and
Tiraboschi, Pietro and Prioni, Sara and Redaelli, Veronica
and Tang-Wai, David and Rogaeva, Ekaterina and
Castelo-Branco, Miguel and Freedman, Morris and Keren, Ron
and Black, Sandra and Mitchell, Sara and Shoesmith, Christen
and Bartha, Robart and Rademakers, Rosa and Poos, Jackie and
Papma, Janne M and Giannini, Lucia and van Minkelen, Rick
and Pijnenburg, Yolande and Ferrari, Camilla and Polito,
Cristina and Lombardi, Gemma and Bessi, Valentina and
Veldsman, Michele and Andersson, Christin and Thonberg,
Hakan and Öijerstedt, Linn and Jelic, Vesna and Thompson,
Paul and Langheinrich, Tobias and Lladó, Albert and
Antonell, Anna and Olives, Jaume and Balasa, Mircea and
Bargalló, Nuria and Borrego-Ecija, Sergi and Verdelho, Ana
and Maruta, Carolina and Ferreira, Catarina B and
Miltenberger, Gabriel and Simões do Couto, Frederico and
Gabilondo, Alazne and Gorostidi, Ana and Villanua, Jorge and
Cañada, Marta and Tainta, Mikel and Zulaica, Miren and
Barandiaran, Myriam and Alves, Patricia and Bender, Benjamin
and Wilke, Carlo and Graf, Lisa and Vogels, Annick and
Vandenbulcke, Mathieu and Van Damme, Philip and Bruffaerts,
Rose and Poesen, Koen and Rosa-Neto, Pedro and Gauthier,
Serge and Camuzat, Agnès and Brice, Alexis and Bertrand,
Anne and Funkiewiez, Aurélie and Rinaldi, Daisy and
Colliot, Olivier and Sayah, Sabrina and Prix, Catharina and
Wlasich, Elisabeth and Wagemann, Olivia and Loosli, Sandra
and Schönecker, Sonja and Hoegen, Tobias and Lombardi,
Jolina and Anderl-Straub, Sarah and Rollin, Adeline and
Kuchcinski, Gregory and Bertoux, Maxime and Lebouvier,
Thibaud and Deramecourt, Vincent and Santiago, Beatriz and
Duro, Diana and Leitão, Maria João and Almeida, Maria
Rosario and Tábuas-Pereira, Miguel and Afonso, Sónia and
Engel, Annerose and Polyakova, Maryna},
title = {{T}emporal dynamics predict symptom onset and cognitive
decline in familial frontotemporal dementia.},
journal = {Alzheimer's and dementia},
volume = {19},
number = {5},
issn = {1552-5260},
address = {Hoboken, NJ},
publisher = {Wiley},
reportid = {DZNE-2022-01704},
pages = {1947-1962},
year = {2023},
abstract = {We tested whether changes in functional networks predict
cognitive decline and conversion from the presymptomatic
prodrome to symptomatic disease in familial frontotemporal
dementia (FTD).For hypothesis generation, 36 participants
with behavioral variant FTD (bvFTD) and 34 controls were
recruited from one site. For hypothesis testing, we studied
198 symptomatic FTD mutation carriers, 341 presymptomatic
mutation carriers, and 329 family members without mutations.
We compared functional network dynamics between groups, with
clinical severity and with longitudinal clinical
progression.We identified a characteristic pattern of
dynamic network changes in FTD, which correlated with
neuropsychological impairment. Among presymptomatic mutation
carriers, this pattern of network dynamics was found to a
greater extent in those who subsequently converted to the
symptomatic phase. Baseline network dynamic changes
predicted future cognitive decline in symptomatic
participants and older presymptomatic participants.Dynamic
network abnormalities in FTD predict cognitive decline and
symptomatic conversion.We investigated brain network
predictors of dementia symptom onset Frontotemporal dementia
results in characteristic dynamic network patterns
Alterations in network dynamics are associated with
neuropsychological impairment Network dynamic changes
predict symptomatic conversion in presymptomatic carriers
Network dynamic changes are associated with longitudinal
cognitive decline.},
keywords = {Humans / Frontotemporal Dementia: diagnosis / Mutation:
genetics / Brain / Cognitive Dysfunction: genetics /
Magnetic Resonance Imaging / disease progression (Other) /
frontotemporal dementia (Other) / functional magnetic
resonance imaging (fMRI) (Other) / network dynamics (Other)
/ presymptomatic (Other)},
cin = {AG Gasser / Clinical Dementia Research München ; AG Levin},
ddc = {610},
cid = {I:(DE-2719)1210000 / I:(DE-2719)1111016},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC7614527},
pubmed = {pmid:36377606},
doi = {10.1002/alz.12824},
url = {https://pub.dzne.de/record/165562},
}
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