000165567 001__ 165567
000165567 005__ 20230908115939.0
000165567 020__ $$a978-1-0716-2596-5 (print)
000165567 020__ $$a978-1-0716-2597-2 (electronic)
000165567 0247_ $$2doi$$a10.1007/978-1-0716-2597-2_9
000165567 0247_ $$2pmid$$apmid:36310200
000165567 0247_ $$2ISSN$$a1064-3745
000165567 0247_ $$2ISSN$$a1940-6029
000165567 0247_ $$2altmetric$$aaltmetric:137888273
000165567 037__ $$aDZNE-2022-01707
000165567 041__ $$aEnglish
000165567 082__ $$a570
000165567 1001_ $$0P:(DE-2719)2812350$$aKaniyappan, Senthilvelrajan$$b0$$eFirst author$$udzne
000165567 245__ $$aMicrofluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease.
000165567 260__ $$aNew York, NY$$bSpringer US$$c2023
000165567 29510 $$aProtein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 9 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2
000165567 300__ $$a111 - 123
000165567 3367_ $$2ORCID$$aBOOK_CHAPTER
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000165567 3367_ $$2BibTeX$$aINBOOK
000165567 3367_ $$2DataCite$$aOutput Types/Book chapter
000165567 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1694167031_31833
000165567 4900_ $$aMethods in Molecular Biology$$v2551
000165567 520__ $$aTau is a microtubule-associated protein found mainly in the axons of neurons in the brain. Abnormal changes in Tau (e.g., aggregation, hyperphosphorylation) are hallmarks of Alzheimer's disease. Two processes of relocalization of Tau may be related to early states of the pathology and have received much attention: (1) the redistribution of Tau within cells (termed 'somatodendritic missorting') and (2) the release and reuptake of Tau from donor to acceptor cells (termed 'spreading'). Because of the tripartite nature of neurons (cell body, dendrites, axons), these changes can be studied by microfluidic chambers (MFCs) which allow separation and observation of Tau in neuronal compartments. In this chapter, we present some methods and research results obtained by using microfluidic devices.
000165567 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000165567 588__ $$aDataset connected to CrossRef Book Series, PubMed, , Journals: pub.dzne.de
000165567 650_7 $$2Other$$aMicrofluidic chambers
000165567 650_7 $$2Other$$aMissorting
000165567 650_7 $$2Other$$aPrimary neurons
000165567 650_7 $$2Other$$aSpreading
000165567 650_7 $$2Other$$aTau
000165567 650_7 $$2NLM Chemicals$$atau Proteins
000165567 650_2 $$2MeSH$$aHumans
000165567 650_2 $$2MeSH$$atau Proteins: metabolism
000165567 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000165567 650_2 $$2MeSH$$aMicrofluidics
000165567 650_2 $$2MeSH$$aNeurons: metabolism
000165567 650_2 $$2MeSH$$aAxons: metabolism
000165567 7001_ $$0P:(DE-2719)2812372$$aBalaji, Varun$$b1$$udzne
000165567 7001_ $$0P:(DE-2719)2810339$$aWang, Yipeng$$b2$$udzne
000165567 7001_ $$0P:(DE-2719)2541671$$aMandelkow, Eckhard$$b3$$eLast author$$udzne
000165567 773__ $$a10.1007/978-1-0716-2597-2_9
000165567 8564_ $$uhttps://pub.dzne.de/record/165567/files/DZNE-2022-01707_Restricted.pdf
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000165567 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812350$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000165567 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812372$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000165567 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810339$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000165567 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2541671$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000165567 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000165567 9141_ $$y2023
000165567 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-09-11
000165567 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-11
000165567 9201_ $$0I:(DE-2719)1013014$$kAG Mandelkow 1$$lStructural Principles of Neurodegeneration$$x0
000165567 9201_ $$0I:(DE-2719)1013015$$kAG Mandelkow 2$$lCell and Animal Models of Neurodegeneration$$x1
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