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| Home > Publications Database > Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. > print |
| 001 | 165567 | ||
| 005 | 20230908115939.0 | ||
| 020 | _ | _ | |a 978-1-0716-2596-5 (print) |
| 020 | _ | _ | |a 978-1-0716-2597-2 (electronic) |
| 024 | 7 | _ | |a 10.1007/978-1-0716-2597-2_9 |2 doi |
| 024 | 7 | _ | |a pmid:36310200 |2 pmid |
| 024 | 7 | _ | |a 1064-3745 |2 ISSN |
| 024 | 7 | _ | |a 1940-6029 |2 ISSN |
| 024 | 7 | _ | |a altmetric:137888273 |2 altmetric |
| 037 | _ | _ | |a DZNE-2022-01707 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Kaniyappan, Senthilvelrajan |0 P:(DE-2719)2812350 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. |
| 260 | _ | _ | |a New York, NY |c 2023 |b Springer US |
| 295 | 1 | 0 | |a Protein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 9 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2 |
| 300 | _ | _ | |a 111 - 123 |
| 336 | 7 | _ | |a BOOK_CHAPTER |2 ORCID |
| 336 | 7 | _ | |a Book Section |0 7 |2 EndNote |
| 336 | 7 | _ | |a bookPart |2 DRIVER |
| 336 | 7 | _ | |a INBOOK |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Book chapter |2 DataCite |
| 336 | 7 | _ | |a Contribution to a book |b contb |m contb |0 PUB:(DE-HGF)7 |s 1694167031_31833 |2 PUB:(DE-HGF) |
| 490 | 0 | _ | |a Methods in Molecular Biology |v 2551 |
| 520 | _ | _ | |a Tau is a microtubule-associated protein found mainly in the axons of neurons in the brain. Abnormal changes in Tau (e.g., aggregation, hyperphosphorylation) are hallmarks of Alzheimer's disease. Two processes of relocalization of Tau may be related to early states of the pathology and have received much attention: (1) the redistribution of Tau within cells (termed 'somatodendritic missorting') and (2) the release and reuptake of Tau from donor to acceptor cells (termed 'spreading'). Because of the tripartite nature of neurons (cell body, dendrites, axons), these changes can be studied by microfluidic chambers (MFCs) which allow separation and observation of Tau in neuronal compartments. In this chapter, we present some methods and research results obtained by using microfluidic devices. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef Book Series, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Microfluidic chambers |2 Other |
| 650 | _ | 7 | |a Missorting |2 Other |
| 650 | _ | 7 | |a Primary neurons |2 Other |
| 650 | _ | 7 | |a Spreading |2 Other |
| 650 | _ | 7 | |a Tau |2 Other |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: metabolism |2 MeSH |
| 650 | _ | 2 | |a Microfluidics |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Axons: metabolism |2 MeSH |
| 700 | 1 | _ | |a Balaji, Varun |0 P:(DE-2719)2812372 |b 1 |u dzne |
| 700 | 1 | _ | |a Wang, Yipeng |0 P:(DE-2719)2810339 |b 2 |u dzne |
| 700 | 1 | _ | |a Mandelkow, Eckhard |0 P:(DE-2719)2541671 |b 3 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1007/978-1-0716-2597-2_9 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/165567/files/DZNE-2022-01707_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/165567/files/DZNE-2022-01707_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:165567 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2812350 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2812372 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)2810339 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2541671 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 0 |
| 914 | 1 | _ | |y 2023 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2020-09-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2020-09-11 |
| 920 | 1 | _ | |0 I:(DE-2719)1013014 |k AG Mandelkow 1 |l Structural Principles of Neurodegeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013015 |k AG Mandelkow 2 |l Cell and Animal Models of Neurodegeneration |x 1 |
| 980 | _ | _ | |a contb |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013014 |
| 980 | _ | _ | |a I:(DE-2719)1013015 |
| 980 | _ | _ | |a UNRESTRICTED |
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