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@ARTICLE{Kempermann:165574,
      author       = {Kempermann, Gerd and Bogado Lopes, Jadna and Zocher, Sara
                      and Schilling, Susan and Ehret, Fanny and Garthe, Alexander
                      and Karasinsky, Anne and Brandmaier, Andreas M and
                      Lindenberger, Ulman and Winter, York and Overall, Rupert W},
      title        = {{T}he individuality paradigm: {A}utomated longitudinal
                      activity tracking of large cohorts of genetically identical
                      mice in an enriched environment.},
      journal      = {Neurobiology of disease},
      volume       = {175},
      issn         = {0969-9961},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2022-01714},
      pages        = {105916},
      year         = {2022},
      abstract     = {Personalized medicine intensifies interest in experimental
                      paradigms that delineate sources of phenotypic variation.
                      The paradigm of environmental enrichment allows for
                      comparisons among differently housed laboratory rodents to
                      unravel environmental effects on brain plasticity and
                      related phenotypes. We have developed a new longitudinal
                      variant of this paradigm, which allows to investigate the
                      emergence of individuality, the divergence of individual
                      behavioral trajectories under a constant genetic background
                      and in a shared environment. We here describe this novel
                      method, the 'Individuality Paradigm,' which allows to
                      investigate mechanisms that drive individuality. Various
                      aspects of individual activity are tracked over time to
                      identify the contribution of the non-shared environment,
                      that is the extent to which the experience of an environment
                      differs between individual members of a population. We
                      describe the design of this paradigm in detail, lay out its
                      scientific potential beyond the published studies and
                      discuss how it differs from other approaches to study
                      individuality. The custom-built cage system, commercially
                      marketed as 'ColonyRack', allows mice to roam freely between
                      70 cages through connector tubes equipped with ring antennas
                      that detect each animal's ID from an RFID transponder
                      implanted in the animal's neck. The system has a total floor
                      area of 2.74 m2 and its spatial resolution corresponds to
                      the size of the individual cages. Spatiotemporally resolved
                      antenna contacts yield longitudinal measures of individual
                      behavior, including the powerful measure of roaming entropy
                      (RE). The Individuality Paradigm provides a rodent model of
                      the making of individuality and the impact of the
                      'non-shared' environment on life-course development.},
      subtyp        = {Review Article},
      keywords     = {Animals / Mice / Individuality / Neuronal Plasticity /
                      Aging (Other) / Behavior (Other) / Brain (Other) /
                      Environmental enrichment (Other) / Gene environment
                      interaction (Other) / Home-cage tracking (Other) /
                      Individuation (Other) / Longitudinal (Other) / Non-shared
                      environment (Other) / Plasticity (Other)},
      cin          = {AG Kempermann / AG Garthe},
      ddc          = {570},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)1740001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36336243},
      doi          = {10.1016/j.nbd.2022.105916},
      url          = {https://pub.dzne.de/record/165574},
}