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000165599 1001_ $$0P:(DE-2719)2811316$$aSchelski, Max$$b0$$eFirst author$$udzne
000165599 245__ $$aMicrotubule retrograde flow retains neuronal polarization in a fluctuating state.
000165599 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2022
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000165599 520__ $$aIn developing vertebrate neurons, a neurite is formed by more than a hundred microtubules. While individual microtubules are dynamic, the microtubule array has been regarded as stationary. Using live-cell imaging of neurons in culture or in brain slices, combined with photoconversion techniques and pharmacological manipulations, we uncovered that the microtubule array flows retrogradely within neurites to the soma. This flow drives cycles of microtubule density, a hallmark of the fluctuating state before axon formation, thereby inhibiting neurite growth. The motor protein dynein fuels this process. Shortly after axon formation, microtubule retrograde flow slows down in the axon, reducing microtubule density cycles and enabling axon extension. Thus, keeping neurites short is an active process. Microtubule retrograde flow is a previously unknown type of cytoskeletal dynamics, which changes the hitherto axon-centric view of neuronal polarization.
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000165599 7001_ $$0P:(DE-2719)2810270$$aBradke, Frank$$b1$$eLast author$$udzne
000165599 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.abo2336$$gVol. 8, no. 44, p. eabo2336$$n44$$peabo2336$$tScience advances$$v8$$x2375-2548$$y2022
000165599 7870_ $$0DZNE-2022-01772$$aBradke, Frank et.al.$$dDryad, 2022$$iRelatedTo$$r$$tMicrotubule retrograde flow retains neuronal polarization in a fluctuating state
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