%0 Journal Article
%A Steward, Anna
%A Biel, Davina
%A Brendel, Matthias
%A Dewenter, Anna
%A Roemer, Sebastian
%A Rubinski, Anna
%A Luan, Ying
%A Dichgans, Martin
%A Ewers, Michael
%A Franzmeier, Nicolai
%T Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease.
%J Alzheimer's and dementia
%V 19
%N 5
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2022-01735
%P 2034-2046
%D 2023
%X Lower network segregation is associated with accelerated cognitive decline in Alzheimer's disease (AD), yet it is unclear whether less segregated brain networks facilitate connectivity-mediated tau spreading.We combined resting state functional magnetic resonance imaging (fMRI) with longitudinal tau positron emission tomography (PET) in 42 betamyloid-negative controls and 81 amyloid beta positive individuals across the AD spectrum. Network segregation was determined using resting-state fMRI-assessed connectivity among 400 cortical regions belonging to seven networks.AD subjects with higher network segregation exhibited slower brain-wide tau accumulation relative to their baseline entorhinal tau PET burden (typical onset site of tau pathology). Second, by identifying patient-specific tau epicenters with highest baseline tau PET we found that stronger epicenter segregation was associated with a slower rate of tau accumulation in the rest of the brain in relation to baseline epicenter tau burden.Our results indicate that tau spreading is facilitated by a more diffusely organized connectome, suggesting that brain network topology modulates tau spreading in AD.Higher brain network segregation is associated with attenuated tau pathology accumulation in Alzheimer's disease (AD). A patient-tailored approach allows for the more precise localization of tau epicenters. The functional segregation of subject-specific tau epicenters predicts the rate of future tau accumulation.
%K Humans
%K Alzheimer Disease: pathology
%K Amyloid beta-Peptides: metabolism
%K Brain: pathology
%K Cognitive Dysfunction: pathology
%K Connectome: methods
%K Magnetic Resonance Imaging: methods
%K Positron-Emission Tomography
%K tau Proteins: metabolism
%K Amyloid beta-Peptides (NLM Chemicals)
%K Alzheimer's disease (Other)
%K functional magnetic resonance imaging (Other)
%K network segregation (Other)
%K tau positron emission tomography (Other)
%K tau spreading (Other)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36433865
%R 10.1002/alz.12867
%U https://pub.dzne.de/record/165602