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000165607 0247_ $$2doi$$a10.1016/j.mcn.2022.103795
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000165607 0247_ $$2ISSN$$a1095-9327
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000165607 041__ $$aEnglish
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000165607 1001_ $$0P:(DE-2719)2810922$$aGarner, Craig$$b0$$eFirst author$$udzne
000165607 245__ $$aSynaptic logistics: The presynaptic scaffold protein Piccolo a nodal point tuning synaptic vesicle recycling, maintenance and integrity.
000165607 260__ $$aSan Diego, Calif.$$bElsevier$$c2023
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000165607 520__ $$aProperly working synapses are one important guarantor for a functional and healthy brain. They are small, densely packed structures, where information is transmitted through the release of neurotransmitters from synaptic vesicles (SVs). The latter cycle within the presynaptic terminal as they first fuse with the plasma membrane to deliver their neurotransmitter, and afterwards become recycled and prepared for a new release event. The synapse is an autonomous structure functioning mostly independent of the neuronal soma. Dysfunction in synaptic processes associated with local insults or genetic abnormalities can directly compromise synapse function and integrity and subsequently lead to the onset of neurodegenerative diseases. Therefore, measures need to be in place counteracting these threats for instance through the continuous replacement of old and damaged SV proteins. Interestingly recent studies show that the presynaptic scaffolding protein Piccolo contributes to health, function and integrity of synapses, as it mediates the delivery of synaptic proteins from the trans-Golgi network (TGN) towards synapses, as well as the local recycling and turnover of SV proteins within synaptic terminals. It can fulfill these various tasks through its multi-domain structure and ability to interact with numerous binding partners. In addition, Piccolo has recently been linked with the early onset neurodegenerative disease Pontocerebellar Hypoplasia Type 3 (PCH3) further underlying its importance for neuronal health. In this review, we will focus on Piccolo's contributions to synapse function, health and integrity and make a connection how those may contribute to the disease pattern of PCH3.
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000165607 650_7 $$2Other$$aNeurodegenerative disease
000165607 650_7 $$2Other$$aPontocerebellar hypoplasia
000165607 650_7 $$2Other$$aPresynaptic scaffolding protein piccolo
000165607 650_7 $$2Other$$aSV recycling
000165607 650_7 $$2Other$$aSynapse health
000165607 650_7 $$2Other$$aSynapse intergrity
000165607 650_2 $$2MeSH$$aOlivopontocerebellar Atrophies
000165607 650_2 $$2MeSH$$aHumans
000165607 650_2 $$2MeSH$$aSynaptic Vesicles: metabolism
000165607 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000165607 650_2 $$2MeSH$$aSynapses: metabolism
000165607 650_2 $$2MeSH$$aPresynaptic Terminals: metabolism
000165607 650_2 $$2MeSH$$aBiological Transport
000165607 7001_ $$0P:(DE-2719)2810967$$aAckermann, Frauke$$b1$$eLast author$$udzne
000165607 773__ $$0PERI:(DE-600)1471177-1$$a10.1016/j.mcn.2022.103795$$gp. 103795 -$$p103795$$tMolecular and cellular neuroscience$$v124$$x1044-7431$$y2023
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