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@ARTICLE{Garner:165607,
      author       = {Garner, Craig and Ackermann, Frauke},
      title        = {{S}ynaptic logistics: {T}he presynaptic scaffold protein
                      {P}iccolo a nodal point tuning synaptic vesicle recycling,
                      maintenance and integrity.},
      journal      = {Molecular and cellular neuroscience},
      volume       = {124},
      issn         = {1044-7431},
      address      = {San Diego, Calif.},
      publisher    = {Elsevier},
      reportid     = {DZNE-2022-01740},
      pages        = {103795},
      year         = {2023},
      abstract     = {Properly working synapses are one important guarantor for a
                      functional and healthy brain. They are small, densely packed
                      structures, where information is transmitted through the
                      release of neurotransmitters from synaptic vesicles (SVs).
                      The latter cycle within the presynaptic terminal as they
                      first fuse with the plasma membrane to deliver their
                      neurotransmitter, and afterwards become recycled and
                      prepared for a new release event. The synapse is an
                      autonomous structure functioning mostly independent of the
                      neuronal soma. Dysfunction in synaptic processes associated
                      with local insults or genetic abnormalities can directly
                      compromise synapse function and integrity and subsequently
                      lead to the onset of neurodegenerative diseases. Therefore,
                      measures need to be in place counteracting these threats for
                      instance through the continuous replacement of old and
                      damaged SV proteins. Interestingly recent studies show that
                      the presynaptic scaffolding protein Piccolo contributes to
                      health, function and integrity of synapses, as it mediates
                      the delivery of synaptic proteins from the trans-Golgi
                      network (TGN) towards synapses, as well as the local
                      recycling and turnover of SV proteins within synaptic
                      terminals. It can fulfill these various tasks through its
                      multi-domain structure and ability to interact with numerous
                      binding partners. In addition, Piccolo has recently been
                      linked with the early onset neurodegenerative disease
                      Pontocerebellar Hypoplasia Type 3 (PCH3) further underlying
                      its importance for neuronal health. In this review, we will
                      focus on Piccolo's contributions to synapse function, health
                      and integrity and make a connection how those may contribute
                      to the disease pattern of PCH3.},
      subtyp        = {Review Article},
      keywords     = {Olivopontocerebellar Atrophies / Humans / Synaptic
                      Vesicles: metabolism / Neurodegenerative Diseases:
                      metabolism / Synapses: metabolism / Presynaptic Terminals:
                      metabolism / Biological Transport / Neurodegenerative
                      disease (Other) / Pontocerebellar hypoplasia (Other) /
                      Presynaptic scaffolding protein piccolo (Other) / SV
                      recycling (Other) / Synapse health (Other) / Synapse
                      intergrity (Other)},
      cin          = {AG Garner / AG Ackermann},
      ddc          = {610},
      cid          = {I:(DE-2719)1810001 / I:(DE-2719)1813004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36436725},
      doi          = {10.1016/j.mcn.2022.103795},
      url          = {https://pub.dzne.de/record/165607},
}