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@ARTICLE{Zambusi:165614,
      author       = {Zambusi, Alessandro and Novoselc, Klara Tereza and Hutten,
                      Saskia and Kalpazidou, Sofia and Koupourtidou, Christina and
                      Schieweck, Rico and Aschenbroich, Sven and Silva, Lara and
                      Yazgili, Ayse Seda and van Bebber, Frauke and Schmid,
                      Bettina and Möller, Gabriel and Tritscher, Clara and
                      Stigloher, Christian and Delbridge, Claire and Sirko,
                      Swetlana and Günes, Zeynep Irem and Liebscher, Sabine and
                      Schlegel, Jürgen and Aliee, Hananeh and Theis, Fabian and
                      Meiners, Silke and Kiebler, Michael and Dormann, Dorothee
                      and Ninkovic, Jovica},
      title        = {{TDP}-43 condensates and lipid droplets regulate the
                      reactivity of microglia and regeneration after traumatic
                      brain injury.},
      journal      = {Nature neuroscience},
      volume       = {25},
      number       = {12},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2022-01747},
      pages        = {1608 - 1625},
      year         = {2022},
      abstract     = {Decreasing the activation of pathology-activated microglia
                      is crucial to prevent chronic inflammation and tissue
                      scarring. In this study, we used a stab wound injury model
                      in zebrafish and identified an injury-induced microglial
                      state characterized by the accumulation of lipid droplets
                      and TAR DNA-binding protein of 43 kDa (TDP-43)+ condensates.
                      Granulin-mediated clearance of both lipid droplets and
                      TDP-43+ condensates was necessary and sufficient to promote
                      the return of microglia back to the basal state and achieve
                      scarless regeneration. Moreover, in postmortem cortical
                      brain tissues from patients with traumatic brain injury, the
                      extent of microglial activation correlated with the
                      accumulation of lipid droplets and TDP-43+ condensates.
                      Together, our results reveal a mechanism required for
                      restoring microglia to a nonactivated state after injury,
                      which has potential for new therapeutic applications in
                      humans.},
      keywords     = {Humans / Animals / Microglia / Lipid Droplets / Zebrafish /
                      Brain Injuries, Traumatic / DNA-Binding Proteins /
                      Regeneration / DNA-Binding Proteins (NLM Chemicals)},
      cin          = {AG Schmid München},
      ddc          = {610},
      cid          = {I:(DE-2719)1140002},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36424432},
      doi          = {10.1038/s41593-022-01199-y},
      url          = {https://pub.dzne.de/record/165614},
}