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@ARTICLE{PintoCosta:169044,
      author       = {Pinto-Costa, Rita and Harbachova, Eugenia and La Vitola,
                      Pietro and Di Monte, Donato Antonio},
      title        = {{O}verexpression-{I}nduced α-{S}ynuclein {B}rain
                      {S}preading.},
      journal      = {Neurotherapeutics},
      volume       = {20},
      number       = {1},
      issn         = {1933-7213},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {DZNE-2022-01766},
      pages        = {83-96},
      year         = {2023},
      abstract     = {Interneuronal transfer of pathological α-synuclein species
                      is thought to play an important role in the progressive
                      advancement of Lewy pathology and increasing severity of
                      clinical manifestations in Parkinson's and other diseases
                      commonly referred to as synucleinopathies.
                      Pathophysiological conditions and mechanisms triggering this
                      trans-synaptic spreading bear therefore significant
                      pathogenetic implications but have yet to be fully
                      elucidated. In vivo experimental models support the
                      conclusion that increased expression of intraneuronal
                      α-synuclein can itself induce protein spreading throughout
                      the brain as well as from the brain to peripheral tissues.
                      For example, overexpression of α-synuclein targeted to the
                      rodent dorsal medulla oblongata results in its transfer and
                      accumulation into recipient axons innervating this brain
                      region; through these axons, α-synuclein can then travel
                      caudo-rostrally and reach other brain sites in the pons,
                      midbrain, and forebrain. When protein overexpression is
                      induced in the rodent midbrain, long-distance α-synuclein
                      spreading can be followed over time; spreading-induced
                      α-synuclein accumulation affects lower brain regions,
                      including the dorsal motor nucleus of the vagus, proceeds
                      through efferent axons of the vagus nerve, and is ultimately
                      detected within vagal motor nerve endings in the gastric
                      wall. As discussed in this review, animal models featuring
                      α-synuclein overexpression not only support a relationship
                      between α-synuclein burden and protein spreading but have
                      also provided important clues on conditions/mechanisms
                      capable of promoting interneuronal α-synuclein transfer.
                      Intriguing findings include the relationship between
                      neuronal activity and protein spreading and the role of
                      oxidant stress in trans-synaptic α-synuclein mobility.},
      subtyp        = {Review Article},
      keywords     = {Animals / alpha-Synuclein: metabolism / Brain: metabolism /
                      Neurons: metabolism / Parkinson Disease: metabolism /
                      Stomach: innervation / Stomach: metabolism / Synaptic
                      Transmission: physiology / Synucleinopathies: metabolism /
                      Vagus Nerve: metabolism / Vagus Nerve: physiology /
                      alpha-Synuclein (NLM Chemicals) / Animal models (Other) /
                      Gut-brain axis (Other) / Neuronal activity (Other) /
                      Oxidative stress (Other) / Parkinson (Other) / Vagus nerve
                      (Other)},
      cin          = {AG Di Monte},
      ddc          = {610},
      cid          = {I:(DE-2719)1013008},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10119350},
      pubmed       = {pmid:36512255},
      doi          = {10.1007/s13311-022-01332-6},
      url          = {https://pub.dzne.de/record/169044},
}