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@MISC{Tavosanis:169074,
      author       = {Tavosanis, Gaia and Prisco, Luigi},
      title        = {{D}ataset: {APL} synapses distribution on {PN} and {KC}
                      meshes, primary data, calcium imaging macros and python
                      scripts from {P}risco et al.},
      publisher    = {Dryad},
      reportid     = {DZNE-2022-01781},
      year         = {2021},
      abstract     = {To identify and memorize discrete but similar environmental
                      inputs, the brain needs to distinguish between subtle
                      differences of activity patterns in defined neuronal
                      populations. The Kenyon cells of the Drosophila adult
                      mushroom body (MB) respond sparsely to complex olfactory
                      input, a property that is thought to support stimuli
                      discrimination in the MB. To understand how this property
                      emerges, we investigated the role of the inhibitory anterior
                      paired lateral neuron (APL) in the input circuit of the MB,
                      the calyx. Within the calyx, presynaptic boutons of
                      projection neurons (PNs) form large synaptic microglomeruli
                      (MGs) with dendrites of postsynaptic Kenyon cells (KCs).
                      Combining EM data analysis and in vivo calcium imaging, we
                      show that APL, via inhibitory and reciprocal synapses
                      targeting both PN boutons and KC dendrites, normalizes
                      odour-evoked representations in MGs of the calyx. APL
                      response scales with the PN input strength and is
                      regionalized around PN input distribution. Our data indicate
                      that the formation of a sparse code by the Kenyon cells
                      requires APL-driven normalization of their MG postsynaptic
                      responses. This work provides experimental insights on how
                      inhibition shapes sensory information representation in a
                      higher brain centre, thereby supporting stimuli
                      discrimination and allowing for efficient associative memory
                      formation.},
      cin          = {AG Tavosanis},
      cid          = {I:(DE-2719)1013018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.5061/dryad.bk3j9kdd1},
      url          = {https://pub.dzne.de/record/169074},
}