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@MISC{Knab:169097,
author = {Knab, Felix and Koch, Stefan Paul and Major, Sebastian and
Farr, Tracy D. and Mueller, Susanne and Euskirchen, Philipp
and Eggers, Moritz and Kuffner, Melanie T. C. and Walter,
Josefine and Dreier, Jens P. and Endres, Matthias and
Dirnagl, Ulrich and Wenger, Nikolaus and Hoffmann, Christian
and Boehm-Sturm, Philipp and Harms, Christoph},
title = {{D}ataset: {O}pen data repository, {K}nab et al.,
{P}rediction of stroke outcome in mice based on non-invasive
{MRI} and behavioral testing, v3.1},
publisher = {Zenodo},
reportid = {DZNE-2022-01804},
year = {2022},
abstract = {Open data repository, Knab et al., Prediction of stroke
outcome in mice based on non-invasive MRI and behavioral
testing Latest version of files: $repository_v2.0.zip$ and
Behavior $Data_v2.0.xlsx,$ please ignore repository.zip Open
data repository Knab et al. Prediction of stroke outcome in
mice based on non-invasvive MRI and behavioral testing
Content: README.txt This information dat Contains MRI data
in NIFTI format and secondary data from atlas registration.
For documentation of atlas registration files see
https://pubmed.ncbi.nlm.nih.gov/28829217/ Files used for the
manuscript: t2.nii: t2 weighted image acquired 24 h post
stroke masklesion.nii: manually delineated lesion
$x_masklesion.nii:$ lesion in atlas space $ix_ANO.nii:$
Allen brain atlas in native space (i.e. matching t2.nii)
Lesion volume was calculated by volume of voxels unequal 0
in $x_masklesion.nii$ Overlap of regions defined by
$ix_ANO.nii$ with masklesion.nii were used for calculating
percent damage in each atlas region $prediction_models$
Contains separated training and test data as xlsx and csv
files with lesion volumes in cubic mm of the Allen brain
atlas space, percent damage per atlas region and behavioral
data. The training data was used as input for training
prediction models in MATLAB, the results were created using
the test data. The files have following sturcture: Column 1:
animal ID Columns 2-537: MRI regions (column title
corresponds to the region number as used in the Allen common
coordinate framework) Column 538: lesion volume Column 539:
initial performance (subacute deficit) = mean
performance/deficit on days 2-6 Column 540: mean
performance/deficit on days 2-6 = initial performance
(subacute deficit) - this column equals column 539 but has
different header which was used to train the residual from
initial deficit Column 541: residual performance/deficit
Column 542: test or training group Consecutive rows contain
data for each animal specified by the animal id The
repository also contains all trained models, prediction
results for the test data and tables with resulting median
absolute error (MedAE) and 5th, 25th, 75th and 95 absolute
error quantiles for each model. The model files end with
$'_models.mat'$ and contain 50 independently trained models
each. Each model version is specified by number 1-50. The
result files end with $'_test_results.mat'$ or
$'_test_results.xlsx',$ files with MedAE and quantiles end
with $'_test_errors.xlsx'$ or $'_test_errors.csv.$ The
common part of filenames specifies the used paradigm Folder
'subacute deficit prediction' contains: -
$initial_performance_from_lesion_volume:$ prediction of
subacute deficit using lesion volume -
$initial_performance_from_segmented_mri:$ prediction of
subacute deficit using segmented mri Folder 'long-term
outcome prediction' contains: - $lesion_volume:$ prediction
of residual deficit using lesion volume - $segmented_mri:$
prediction of residual deficit using $segmented_mri$ -
$initial_performance:$ prediction of residual deficit using
subacute deficit Folder $'mri_inc_oob_imp'$ contains models
trained using increasing number of mri segments sorted
according to the out-of-bag importance. The number of used
segments is given in the file name. The models, results and
errors are separated in subfolders. Files with equal file
name and different extension always contain the same data
templates Allen atlas, template, brain mask, hemisphere
masks, tissue probability masks in NIFTI format including
annotations of region IDs and parameter.m file for use in
MATLAB toolbox ANTx2},
keywords = {stroke (Other) / mice (Other) / outcome prediction (Other)
/ motor-function (Other) / staircase (Other)},
cin = {AG Endres / AG Dirnagl},
cid = {I:(DE-2719)1811005 / I:(DE-2719)1810002},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)32},
doi = {10.5281/zenodo.7331723},
url = {https://pub.dzne.de/record/169097},
}