%0 Journal Article
%A Felsky, Daniel
%A Santa-Maria, Ismael
%A Cosacak, Mehmet Ilyas
%A French, Leon
%A Schneider, Julie A
%A Bennett, David A
%A De Jager, Philip L
%A Kizil, Caghan
%A Tosto, Giuseppe
%T The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms.
%J Neurobiology of disease
%V 176
%@ 0969-9961
%C [Amsterdam]
%I Elsevier
%M DZNE-2023-00008
%P 105938
%D 2023
%X Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differential expression (DE) and consensus network-based analyses in RNA-sequencing data of postmortem brain tissue from 39 Caribbean Hispanics (CH). To identify ancestry-concordant and -discordant expression profiles, we compared our results to those from two independent non-Hispanic White (NHW) samples (n = 731). In CH, we identified 2802 significant DE genes, including several LOAD known-loci. DE effects were highly concordant across ethnicities, with 373 genes transcriptome-wide significant in all three cohorts. Cross-ancestry meta-analysis found NPNT to be the top DE gene. We replicated over 82
%K Humans
%K Transcriptome
%K Alzheimer Disease: genetics
%K Caribbean People
%K Ethnicity
%K Brain
%K Genetic Predisposition to Disease
%K Polymorphism, Single Nucleotide
%K LDL-Receptor Related Proteins: genetics
%K Membrane Transport Proteins: genetics
%K Alzheimer's disease (Other)
%K Brain gene expression (Other)
%K Bulk tissue (Other)
%K Caribbean-Hispanic (Other)
%K Single cell (Other)
%K SORL1 protein, human (NLM Chemicals)
%K LDL-Receptor Related Proteins (NLM Chemicals)
%K Membrane Transport Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC10039465
%$ pmid:36462719
%R 10.1016/j.nbd.2022.105938
%U https://pub.dzne.de/record/169129