000169129 001__ 169129
000169129 005__ 20240403131746.0
000169129 0247_ $$2pmc$$apmc:PMC10039465
000169129 0247_ $$2doi$$a10.1016/j.nbd.2022.105938
000169129 0247_ $$2pmid$$apmid:36462719
000169129 0247_ $$2ISSN$$a0969-9961
000169129 0247_ $$2ISSN$$a1095-953X
000169129 0247_ $$2altmetric$$aaltmetric:139675774
000169129 037__ $$aDZNE-2023-00008
000169129 041__ $$aEnglish
000169129 082__ $$a570
000169129 1001_ $$aFelsky, Daniel$$b0
000169129 245__ $$aThe Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms.
000169129 260__ $$a[Amsterdam]$$bElsevier$$c2023
000169129 3367_ $$2DRIVER$$aarticle
000169129 3367_ $$2DataCite$$aOutput Types/Journal article
000169129 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1672827460_30810
000169129 3367_ $$2BibTeX$$aARTICLE
000169129 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000169129 3367_ $$00$$2EndNote$$aJournal Article
000169129 520__ $$aIdentifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differential expression (DE) and consensus network-based analyses in RNA-sequencing data of postmortem brain tissue from 39 Caribbean Hispanics (CH). To identify ancestry-concordant and -discordant expression profiles, we compared our results to those from two independent non-Hispanic White (NHW) samples (n = 731). In CH, we identified 2802 significant DE genes, including several LOAD known-loci. DE effects were highly concordant across ethnicities, with 373 genes transcriptome-wide significant in all three cohorts. Cross-ancestry meta-analysis found NPNT to be the top DE gene. We replicated over 82% of meta-analyses genome-wide signals in single-nucleus RNA-seq data (including NPNT and LOAD known-genes SORL1, FBXL7, CLU, ABCA7). Increasing representation in genetic studies will allow for deeper understanding of ancestry-specific mechanisms and improving precision treatment options in understudied groups.
000169129 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000169129 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000169129 650_7 $$2Other$$aAlzheimer's disease
000169129 650_7 $$2Other$$aBrain gene expression
000169129 650_7 $$2Other$$aBulk tissue
000169129 650_7 $$2Other$$aCaribbean-Hispanic
000169129 650_7 $$2Other$$aSingle cell
000169129 650_7 $$2NLM Chemicals$$aSORL1 protein, human
000169129 650_7 $$2NLM Chemicals$$aLDL-Receptor Related Proteins
000169129 650_7 $$2NLM Chemicals$$aMembrane Transport Proteins
000169129 650_2 $$2MeSH$$aHumans
000169129 650_2 $$2MeSH$$aTranscriptome
000169129 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000169129 650_2 $$2MeSH$$aCaribbean People
000169129 650_2 $$2MeSH$$aEthnicity
000169129 650_2 $$2MeSH$$aBrain
000169129 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000169129 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000169129 650_2 $$2MeSH$$aLDL-Receptor Related Proteins: genetics
000169129 650_2 $$2MeSH$$aMembrane Transport Proteins: genetics
000169129 7001_ $$aSanta-Maria, Ismael$$b1
000169129 7001_ $$0P:(DE-2719)2811286$$aCosacak, Mehmet Ilyas$$b2
000169129 7001_ $$aFrench, Leon$$b3
000169129 7001_ $$aSchneider, Julie A$$b4
000169129 7001_ $$aBennett, David A$$b5
000169129 7001_ $$aDe Jager, Philip L$$b6
000169129 7001_ $$0P:(DE-2719)2811030$$aKizil, Caghan$$b7
000169129 7001_ $$0P:(DE-HGF)0$$aTosto, Giuseppe$$b8$$eCorresponding author
000169129 773__ $$0PERI:(DE-600)1471408-5$$a10.1016/j.nbd.2022.105938$$gVol. 176, p. 105938 -$$p105938$$tNeurobiology of disease$$v176$$x0969-9961$$y2023
000169129 8564_ $$uhttps://pub.dzne.de/record/169129/files/DZNE-2023-00008-SUP.zip
000169129 8564_ $$uhttps://pub.dzne.de/record/169129/files/DZNE-2023-00008.pdf$$yOpenAccess
000169129 8564_ $$uhttps://pub.dzne.de/record/169129/files/DZNE-2023-00008.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000169129 909CO $$ooai:pub.dzne.de:169129$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000169129 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811286$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000169129 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811030$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000169129 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000169129 9141_ $$y2023
000169129 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-18
000169129 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-23
000169129 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000169129 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROBIOL DIS : 2022$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-04-12T14:49:08Z
000169129 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-18
000169129 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-04-12T14:49:08Z
000169129 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000169129 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2022-11-18
000169129 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROBIOL DIS : 2022$$d2023-08-23
000169129 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-18
000169129 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2022-11-18
000169129 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-04-12T14:49:08Z
000169129 9201_ $$0I:(DE-2719)1710007$$kAG Kizil$$lMechanisms of induced plasticity of the vertebrate brain$$x0
000169129 980__ $$ajournal
000169129 980__ $$aVDB
000169129 980__ $$aUNRESTRICTED
000169129 980__ $$aI:(DE-2719)1710007
000169129 9801_ $$aFullTexts