000169130 001__ 169130
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000169130 0247_ $$2doi$$a10.1016/j.neurobiolaging.2022.05.015
000169130 0247_ $$2pmid$$apmid:36476760
000169130 0247_ $$2ISSN$$a0197-4580
000169130 0247_ $$2ISSN$$a1558-1497
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000169130 037__ $$aDZNE-2023-00009
000169130 041__ $$aEnglish
000169130 082__ $$a610
000169130 1001_ $$aErsoezlue, Ersin$$b0
000169130 245__ $$aLifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease.
000169130 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2022
000169130 3367_ $$2DRIVER$$aarticle
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000169130 520__ $$aAlzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.
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000169130 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000169130 650_7 $$2Other$$aAlzheimer's disease
000169130 650_7 $$2Other$$aCognitive reserve
000169130 650_7 $$2Other$$aDefault-mode network
000169130 650_7 $$2Other$$aFunctional MRI
000169130 650_7 $$2Other$$aLifelong experiences
000169130 650_7 $$2Other$$aNeural reserve
000169130 650_2 $$2MeSH$$aHumans
000169130 650_2 $$2MeSH$$aAlzheimer Disease
000169130 650_2 $$2MeSH$$aCognitive Reserve
000169130 650_2 $$2MeSH$$aBrain Mapping
000169130 650_2 $$2MeSH$$aCognition
000169130 650_2 $$2MeSH$$aBrain: diagnostic imaging
000169130 650_2 $$2MeSH$$aCognitive Dysfunction
000169130 650_2 $$2MeSH$$aAmyloid beta-Peptides
000169130 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000169130 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000169130 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris-Stephan$$b1
000169130 7001_ $$aSchneider-Axmann, Thomas$$b2
000169130 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b3
000169130 7001_ $$0P:(DE-2719)9000476$$aBallarini, Tommaso$$b4
000169130 7001_ $$aTato, Maia$$b5
000169130 7001_ $$0P:(DE-2719)9000381$$aUtecht, Julia$$b6
000169130 7001_ $$0P:(DE-2719)9000176$$aKurz, Carolin$$b7
000169130 7001_ $$aPapazov, Boris$$b8
000169130 7001_ $$0P:(DE-2719)9001027$$aGuersel, Selim$$b9
000169130 7001_ $$aBurow, Lena$$b10
000169130 7001_ $$aKoller, Gabriele$$b11
000169130 7001_ $$aStöcklein, Sophia$$b12
000169130 7001_ $$aKeeser, Daniel$$b13
000169130 7001_ $$0P:(DE-2719)9000444$$aBartels, Claudia$$b14
000169130 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b15
000169130 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b16
000169130 7001_ $$0P:(DE-2719)9001901$$aCetindag, Arda C$$b17
000169130 7001_ $$aDechent, Peter$$b18
000169130 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b19
000169130 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b20
000169130 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b21
000169130 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b22
000169130 7001_ $$aHaynes, John D$$b23
000169130 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b24
000169130 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b25$$udzne
000169130 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b26
000169130 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b27
000169130 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b28
000169130 7001_ $$aMaier, Franziska$$b29
000169130 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline D$$b30
000169130 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b31
000169130 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b32
000169130 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b33
000169130 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b34
000169130 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b35
000169130 7001_ $$0P:(DE-2719)2810395$$aRoeske, Sandra$$b36
000169130 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b37
000169130 7001_ $$aScheffler, Klaus$$b38
000169130 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b39
000169130 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b40
000169130 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike J$$b41
000169130 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b42
000169130 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b43
000169130 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b44
000169130 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b45
000169130 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b46
000169130 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b47
000169130 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b48$$eLast author
000169130 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2022.05.015$$gVol. 122, p. 33 - 44$$p33 - 44$$tNeurobiology of aging$$v122$$x0197-4580$$y2022
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