TY  - JOUR
AU  - Ersoezlue, Ersin
AU  - Rauchmann, Boris-Stephan
AU  - Schneider-Axmann, Thomas
AU  - Wagner, Michael
AU  - Ballarini, Tommaso
AU  - Tato, Maia
AU  - Utecht, Julia
AU  - Kurz, Carolin
AU  - Papazov, Boris
AU  - Guersel, Selim
AU  - Burow, Lena
AU  - Koller, Gabriele
AU  - Stöcklein, Sophia
AU  - Keeser, Daniel
AU  - Bartels, Claudia
AU  - Brosseron, Frederic
AU  - Bürger, Katharina
AU  - Cetindag, Arda C
AU  - Dechent, Peter
AU  - Dobisch, Laura
AU  - Ewers, Michael
AU  - Fliessbach, Klaus
AU  - Frommann, Ingo
AU  - Haynes, John D
AU  - Heneka, Michael T
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Kleineidam, Luca
AU  - Laske, Christoph
AU  - Maier, Franziska
AU  - Metzger, Coraline D
AU  - Munk, Matthias H
AU  - Peters, Oliver
AU  - Preis, Lukas
AU  - Priller, Josef
AU  - Ramirez, Alfredo
AU  - Roeske, Sandra
AU  - Roy, Nina
AU  - Scheffler, Klaus
AU  - Schneider, Anja
AU  - Spottke, Annika
AU  - Spruth, Eike J
AU  - Teipel, Stefan
AU  - Wiltfang, Jens
AU  - Wolfsgruber, Steffen
AU  - Yakupov, Renat
AU  - Düzel, Emrah
AU  - Jessen, Frank
AU  - Perneczky, Robert
TI  - Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease.
JO  - Neurobiology of aging
VL  - 122
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2023-00009
SP  - 33 - 44
PY  - 2022
AB  - Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.
KW  - Humans
KW  - Alzheimer Disease
KW  - Cognitive Reserve
KW  - Brain Mapping
KW  - Cognition
KW  - Brain: diagnostic imaging
KW  - Cognitive Dysfunction
KW  - Amyloid beta-Peptides
KW  - Magnetic Resonance Imaging
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Alzheimer's disease (Other)
KW  - Cognitive reserve (Other)
KW  - Default-mode network (Other)
KW  - Functional MRI (Other)
KW  - Lifelong experiences (Other)
KW  - Neural reserve (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36476760
DO  - DOI:10.1016/j.neurobiolaging.2022.05.015
UR  - https://pub.dzne.de/record/169130
ER  -