% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ersoezlue:169130,
      author       = {Ersoezlue, Ersin and Rauchmann, Boris-Stephan and
                      Schneider-Axmann, Thomas and Wagner, Michael and Ballarini,
                      Tommaso and Tato, Maia and Utecht, Julia and Kurz, Carolin
                      and Papazov, Boris and Guersel, Selim and Burow, Lena and
                      Koller, Gabriele and Stöcklein, Sophia and Keeser, Daniel
                      and Bartels, Claudia and Brosseron, Frederic and Bürger,
                      Katharina and Cetindag, Arda C and Dechent, Peter and
                      Dobisch, Laura and Ewers, Michael and Fliessbach, Klaus and
                      Frommann, Ingo and Haynes, John D and Heneka, Michael T and
                      Janowitz, Daniel and Kilimann, Ingo and Kleineidam, Luca and
                      Laske, Christoph and Maier, Franziska and Metzger, Coraline
                      D and Munk, Matthias H and Peters, Oliver and Preis, Lukas
                      and Priller, Josef and Ramirez, Alfredo and Roeske, Sandra
                      and Roy, Nina and Scheffler, Klaus and Schneider, Anja and
                      Spottke, Annika and Spruth, Eike J and Teipel, Stefan and
                      Wiltfang, Jens and Wolfsgruber, Steffen and Yakupov, Renat
                      and Düzel, Emrah and Jessen, Frank and Perneczky, Robert},
      title        = {{L}ifelong experiences as a proxy of cognitive reserve
                      moderate the association between connectivity and cognition
                      in {A}lzheimer's disease.},
      journal      = {Neurobiology of aging},
      volume       = {122},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2023-00009},
      pages        = {33 - 44},
      year         = {2022},
      abstract     = {Alzheimer's disease (AD) is associated with alterations in
                      functional connectivity (FC) of the brain. The FC
                      underpinnings of CR, that is, lifelong experiences, are
                      largely unknown. Resting-state FC and structural MRI were
                      performed in 76 CSF amyloid-β (Aβ) negative healthy
                      controls and 152 Aβ positive individuals as an AD spectrum
                      cohort (ADS; 55 with subjective cognitive decline, SCD; 52
                      with mild cognitive impairment; 45 with AD dementia).
                      Following a region-of-interest (ROI) FC analysis, intrinsic
                      network connectivity within the default-mode network
                      (INC-DMN) and anti-correlation in INC between the DMN and
                      dorsal attention network (DMN:DAN) were obtained as
                      composite scores. CR was estimated by education and Lifetime
                      Experiences Questionnaire (LEQ). The association between
                      INC-DMN and MEM was attenuated by higher LEQ scores in the
                      entire ADS group, particularly in SCD. In ROI analyses,
                      higher LEQ scores were associated with higher FC within the
                      DMN in ADS group. INC-DMN remains relatively intact despite
                      memory decline in individuals with higher lifetime activity
                      estimates, supporting a role for functional networks in
                      maintaining cognitive function in AD.},
      keywords     = {Humans / Alzheimer Disease / Cognitive Reserve / Brain
                      Mapping / Cognition / Brain: diagnostic imaging / Cognitive
                      Dysfunction / Amyloid beta-Peptides / Magnetic Resonance
                      Imaging / Amyloid beta-Peptides (NLM Chemicals) /
                      Alzheimer's disease (Other) / Cognitive reserve (Other) /
                      Default-mode network (Other) / Functional MRI (Other) /
                      Lifelong experiences (Other) / Neural reserve (Other)},
      cin          = {AG Dichgans / AG Simons / AG Wagner / Biomarker / AG Düzel
                      / Patient Studies Bonn / AG Teipel / AG Gasser / Core
                      Technical Staff / AG Dirnagl / AG Endres / AG Priller /
                      Clinical Research Platform (CRP) / AG Schneider / AG Jessen
                      / AG Levin / Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022 / I:(DE-2719)1110008 /
                      I:(DE-2719)1011201 / I:(DE-2719)1011301 / I:(DE-2719)5000006
                      / I:(DE-2719)1011101 / I:(DE-2719)1510100 /
                      I:(DE-2719)1210000 / I:(DE-2719)1340007 / I:(DE-2719)1810002
                      / I:(DE-2719)1811005 / I:(DE-2719)5000007 /
                      I:(DE-2719)1011401 / I:(DE-2719)1011305 / I:(DE-2719)1011102
                      / I:(DE-2719)1111016 / I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 351 -
                      Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36476760},
      doi          = {10.1016/j.neurobiolaging.2022.05.015},
      url          = {https://pub.dzne.de/record/169130},
}