Home > Publications Database > Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease. > print

001     169130
005     20240826165948.0
024 7 _ |a 10.1016/j.neurobiolaging.2022.05.015
|2 doi
024 7 _ |a pmid:36476760
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024 7 _ |a 0197-4580
|2 ISSN
024 7 _ |a 1558-1497
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024 7 _ |a altmetric:139950742
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037 _ _ |a DZNE-2023-00009
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ersoezlue, Ersin
|b 0
245 _ _ |a Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease.
260 _ _ |a Amsterdam [u.a.]
|c 2022
|b Elsevier Science
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.
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650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a Cognitive reserve
|2 Other
650 _ 7 |a Default-mode network
|2 Other
650 _ 7 |a Functional MRI
|2 Other
650 _ 7 |a Lifelong experiences
|2 Other
650 _ 7 |a Neural reserve
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease
|2 MeSH
650 _ 2 |a Cognitive Reserve
|2 MeSH
650 _ 2 |a Brain Mapping
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Cognitive Dysfunction
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
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|e Longitudinal Cognitive Impairment and Dementia Study
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700 1 _ |a Rauchmann, Boris-Stephan
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700 1 _ |a Schneider-Axmann, Thomas
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700 1 _ |a Wagner, Michael
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700 1 _ |a Burow, Lena
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700 1 _ |a Koller, Gabriele
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700 1 _ |a Stöcklein, Sophia
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700 1 _ |a Keeser, Daniel
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700 1 _ |a Bartels, Claudia
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700 1 _ |a Brosseron, Frederic
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700 1 _ |a Bürger, Katharina
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700 1 _ |a Cetindag, Arda C
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700 1 _ |a Dechent, Peter
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700 1 _ |a Dobisch, Laura
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700 1 _ |a Ewers, Michael
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700 1 _ |a Fliessbach, Klaus
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700 1 _ |a Frommann, Ingo
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700 1 _ |a Haynes, John D
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700 1 _ |a Heneka, Michael T
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700 1 _ |a Janowitz, Daniel
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700 1 _ |a Kilimann, Ingo
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700 1 _ |a Kleineidam, Luca
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700 1 _ |a Laske, Christoph
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700 1 _ |a Maier, Franziska
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700 1 _ |a Metzger, Coraline D
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700 1 _ |a Munk, Matthias H
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700 1 _ |a Peters, Oliver
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700 1 _ |a Preis, Lukas
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700 1 _ |a Priller, Josef
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700 1 _ |a Ramirez, Alfredo
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700 1 _ |a Roeske, Sandra
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700 1 _ |a Roy, Nina
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700 1 _ |a Scheffler, Klaus
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700 1 _ |a Schneider, Anja
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700 1 _ |a Spottke, Annika
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700 1 _ |a Spruth, Eike J
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700 1 _ |a Teipel, Stefan
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700 1 _ |a Wiltfang, Jens
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700 1 _ |a Wolfsgruber, Steffen
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700 1 _ |a Yakupov, Renat
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700 1 _ |a Düzel, Emrah
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700 1 _ |a Jessen, Frank
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700 1 _ |a Perneczky, Robert
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773 _ _ |a 10.1016/j.neurobiolaging.2022.05.015
|g Vol. 122, p. 33 - 44
|0 PERI:(DE-600)1498414-3
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|t Neurobiology of aging
|v 122
|y 2022
|x 0197-4580
856 4 _ |u https://pub.dzne.de/record/169130/files/DZNE-2023-00009_Restricted.pdf
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