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000169133 1001_ $$aKim, Tae-Kyung$$b0
000169133 245__ $$aInflammation promotes synucleinopathy propagation.
000169133 260__ $$aSeoul$$bSoc.$$c2022
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000169133 520__ $$aThe clinical progression of neurodegenerative diseases correlates with the spread of proteinopathy in the brain. The current understanding of the mechanism of proteinopathy spread is far from complete. Here, we propose that inflammation is fundamental to proteinopathy spread. A sequence variant of α-synuclein (V40G) was much less capable of fibril formation than wild-type α-synuclein (WT-syn) and, when mixed with WT-syn, interfered with its fibrillation. However, when V40G was injected intracerebrally into mice, it induced aggregate spreading even more effectively than WT-syn. Aggregate spreading was preceded by sustained microgliosis and inflammatory responses, which were more robust with V40G than with WT-syn. Oral administration of an anti-inflammatory agent suppressed aggregate spreading, inflammation, and behavioral deficits in mice. Furthermore, exposure of cells to inflammatory cytokines increased the cell-to-cell propagation of α-synuclein. These results suggest that the inflammatory microenvironment is the major driver of the spread of synucleinopathy in the brain.
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000169133 650_7 $$2NLM Chemicals$$aalpha-Synuclein
000169133 650_2 $$2MeSH$$aMice
000169133 650_2 $$2MeSH$$aAnimals
000169133 650_2 $$2MeSH$$aalpha-Synuclein: genetics
000169133 650_2 $$2MeSH$$aalpha-Synuclein: metabolism
000169133 650_2 $$2MeSH$$aSynucleinopathies
000169133 650_2 $$2MeSH$$aBrain: metabolism
000169133 650_2 $$2MeSH$$aNeurodegenerative Diseases
000169133 650_2 $$2MeSH$$aInflammation
000169133 650_2 $$2MeSH$$aDisease Models, Animal
000169133 7001_ $$0P:(DE-2719)9000874$$aBae, Eun-Jin$$b1
000169133 7001_ $$aJung, Byung Chul$$b2
000169133 7001_ $$aChoi, Minsun$$b3
000169133 7001_ $$aShin, Soo Jean$$b4
000169133 7001_ $$aPark, Sung Jun$$b5
000169133 7001_ $$aKim, Jeong Tae$$b6
000169133 7001_ $$aJung, Min Kyo$$b7
000169133 7001_ $$0P:(DE-2719)2772760$$aUlusoy, Ayse$$b8
000169133 7001_ $$aSong, Mi-Young$$b9
000169133 7001_ $$aLee, Jun Sung$$b10
000169133 7001_ $$aLee, He-Jin$$b11
000169133 7001_ $$0P:(DE-2719)2481741$$aDi Monte, Donato A$$b12
000169133 7001_ $$0P:(DE-HGF)0$$aLee, Seung-Jae$$b13$$eCorresponding author
000169133 77318 $$2Crossref$$3journal-article$$a10.1038/s12276-022-00895-w$$bSpringer Science and Business Media LLC$$d2022-12-06$$n12$$p2148-2161$$tExperimental & Molecular Medicine$$v54$$x2092-6413$$y2022
000169133 773__ $$0PERI:(DE-600)2084833-X$$a10.1038/s12276-022-00895-w$$gVol. 54, no. 12, p. 2148 - 2161$$n12$$p2148-2161$$tExperimental & molecular medicine$$v54$$x2092-6413$$y2022
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