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000169135 1001_ $$00000-0002-9769-367X$$aMcNamara, Niamh B$$b0
000169135 245__ $$aMicroglia regulate central nervous system myelin growth and integrity.
000169135 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2023
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000169135 520__ $$aMyelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown which macrophage populations are involved and which aspects they influence. Here we show that resident microglia are crucial for the maintenance of myelin health in adulthood in both mice and humans. We demonstrate that microglia are dispensable for developmental myelin ensheathment. However, they are required for subsequent regulation of myelin growth and associated cognitive function, and for preservation of myelin integrity by preventing its degeneration. We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFβ1-TGFβR1 axis. Our findings highlight microglia as promising therapeutic targets for conditions in which myelin growth and integrity are dysregulated, such as in ageing and neurodegenerative disease2,3.
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000169135 650_7 $$2NLM Chemicals$$aTransforming Growth Factor beta1
000169135 650_7 $$0EC 2.7.11.30$$2NLM Chemicals$$aReceptor, Transforming Growth Factor-beta Type I
000169135 650_2 $$2MeSH$$aCentral Nervous System: cytology
000169135 650_2 $$2MeSH$$aHumans
000169135 650_2 $$2MeSH$$aMice
000169135 650_2 $$2MeSH$$aAnimals
000169135 650_2 $$2MeSH$$aAdult
000169135 650_2 $$2MeSH$$aMyelin Sheath: metabolism
000169135 650_2 $$2MeSH$$aMicroglia: metabolism
000169135 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000169135 650_2 $$2MeSH$$aCentral Nervous System: metabolism
000169135 650_2 $$2MeSH$$aAxons: metabolism
000169135 650_2 $$2MeSH$$aOligodendroglia
000169135 650_2 $$2MeSH$$aCentral Nervous System: pathology
000169135 650_2 $$2MeSH$$aMicroglia: cytology
000169135 650_2 $$2MeSH$$aMicroglia: pathology
000169135 650_2 $$2MeSH$$aMyelin Sheath: pathology
000169135 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000169135 650_2 $$2MeSH$$aOligodendroglia: metabolism
000169135 650_2 $$2MeSH$$aOligodendroglia: pathology
000169135 650_2 $$2MeSH$$aCognition
000169135 650_2 $$2MeSH$$aTransforming Growth Factor beta1: metabolism
000169135 650_2 $$2MeSH$$aReceptor, Transforming Growth Factor-beta Type I: metabolism
000169135 650_2 $$2MeSH$$aLipid Metabolism
000169135 650_2 $$2MeSH$$aAging: metabolism
000169135 650_2 $$2MeSH$$aAging: pathology
000169135 7001_ $$aMunro, David A D$$b1
000169135 7001_ $$aBestard-Cuche, Nadine$$b2
000169135 7001_ $$aUyeda, Akiko$$b3
000169135 7001_ $$aBogie, Jeroen F J$$b4
000169135 7001_ $$aHoffmann, Alana$$b5
000169135 7001_ $$00000-0002-9396-7776$$aHolloway, Rebecca K$$b6
000169135 7001_ $$00000-0001-5966-0351$$aMolina-Gonzalez, Irene$$b7
000169135 7001_ $$aAskew, Katharine E$$b8
000169135 7001_ $$aMitchell, Stephen$$b9
000169135 7001_ $$aMungall, William$$b10
000169135 7001_ $$aDodds, Michael$$b11
000169135 7001_ $$aDittmayer, Carsten$$b12
000169135 7001_ $$aMoss, Jonathan$$b13
000169135 7001_ $$aRose, Jamie$$b14
000169135 7001_ $$aSzymkowiak, Stefan$$b15
000169135 7001_ $$00000-0002-8363-373X$$aAmann, Lukas$$b16
000169135 7001_ $$00000-0002-0521-9656$$aMcColl, Barry W$$b17
000169135 7001_ $$00000-0002-0349-1955$$aPrinz, Marco$$b18
000169135 7001_ $$00000-0003-2530-0598$$aSpires-Jones, Tara L$$b19
000169135 7001_ $$aStenzel, Werner$$b20
000169135 7001_ $$aHorsburgh, Karen$$b21
000169135 7001_ $$00000-0002-7717-8582$$aHendriks, Jerome J A$$b22
000169135 7001_ $$00000-0001-9423-557X$$aPridans, Clare$$b23
000169135 7001_ $$00000-0001-5342-7823$$aMuramatsu, Rieko$$b24
000169135 7001_ $$00000-0002-6329-382X$$aWilliams, Anna$$b25
000169135 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b26
000169135 7001_ $$00000-0003-1738-0647$$aMiron, Veronique E$$b27$$eCorresponding author
000169135 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-022-05534-y$$gVol. 613, no. 7942, p. 120 - 129$$n7942$$p120 - 129$$tNature <London>$$v613$$x0028-0836$$y2023
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