000169142 001__ 169142
000169142 005__ 20240722121855.0
000169142 0247_ $$2doi$$a10.3390/ijms232314554
000169142 0247_ $$2pmid$$apmid:36498882
000169142 0247_ $$2pmc$$apmc:PMC9738832
000169142 0247_ $$2ISSN$$a1422-0067
000169142 0247_ $$2ISSN$$a1661-6596
000169142 0247_ $$2altmetric$$aaltmetric:138767676
000169142 037__ $$aDZNE-2023-00021
000169142 041__ $$aEnglish
000169142 082__ $$a540
000169142 1001_ $$00000-0001-7630-0091$$aSimoes, Fabio A$$b0
000169142 245__ $$aPotential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy.
000169142 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
000169142 3367_ $$2DRIVER$$aarticle
000169142 3367_ $$2DataCite$$aOutput Types/Journal article
000169142 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1721636180_12031
000169142 3367_ $$2BibTeX$$aARTICLE
000169142 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000169142 3367_ $$00$$2EndNote$$aJournal Article
000169142 520__ $$aObjective markers for the neurodegenerative disorder progressive supranuclear palsy (PSP) are needed to provide a timely diagnosis with greater certainty. Non-coding RNA (ncRNA), including microRNA, piwi-interacting RNA, and transfer RNA, are good candidate markers in other neurodegenerative diseases, but have not been investigated in PSP. Therefore, as proof of principle, we sought to identify whether they were dysregulated in matched serum and cerebrospinal fluid (CSF) samples of patients with PSP. Small RNA-seq was undertaken on serum and CSF samples from healthy controls (n = 20) and patients with PSP (n = 31) in two cohorts, with reverse transcription-quantitative PCR (RT-qPCR) to confirm their dysregulation. Using RT-qPCR, we found in serum significant down-regulation in hsa-miR-92a-3p, hsa-miR-626, hsa-piR-31068, and tRNA-ValCAC. In CSF, both hsa-let-7a-5p and hsa-piR-31068 showed significant up-regulation, consistent with their changes observed in the RNA-seq results. Interestingly, we saw no correlation in the expression of hsa-piR-31068 within our matched serum and CSF samples, suggesting there is no common dysregulatory mechanism between the two biofluids. While these changes were in a small cohort of samples, we have provided novel evidence that ncRNA in biofluids could be possible diagnostic biomarkers for PSP and further work will help to expand this potential.
000169142 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000169142 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000169142 650_7 $$2Other$$aPSP
000169142 650_7 $$2Other$$aRNA-seq
000169142 650_7 $$2Other$$abiomarker
000169142 650_7 $$2Other$$anon-coding RNA
000169142 650_7 $$2Other$$aprogressive supranuclear palsy
000169142 650_7 $$2NLM Chemicals$$aBiomarkers
000169142 650_7 $$2NLM Chemicals$$aMicroRNAs
000169142 650_2 $$2MeSH$$aHumans
000169142 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive: diagnosis
000169142 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive: genetics
000169142 650_2 $$2MeSH$$aBiomarkers
000169142 650_2 $$2MeSH$$aMicroRNAs: genetics
000169142 650_2 $$2MeSH$$aDown-Regulation
000169142 7001_ $$00000-0001-5827-6382$$aJoilin, Greig$$b1
000169142 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b2$$udzne
000169142 7001_ $$00000-0001-5822-1744$$aSchneider, Luisa-Sophie$$b3
000169142 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b4$$udzne
000169142 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b5$$udzne
000169142 7001_ $$0P:(DE-2719)2811226$$aVogt, Ina Rosemarie$$b6$$udzne
000169142 7001_ $$0P:(DE-2719)9002382$$aKimmich, Okka$$b7$$udzne
000169142 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b8$$udzne
000169142 7001_ $$0P:(DE-2719)2812665$$aHoffmann, Daniel C$$b9$$udzne
000169142 7001_ $$0P:(DE-2719)2814178$$aFalkenburger, Björn$$b10$$udzne
000169142 7001_ $$0P:(DE-2719)2812107$$aBrandt, Moritz$$b11$$udzne
000169142 7001_ $$0P:(DE-2719)2380559$$aPrudlo, Johannes$$b12$$udzne
000169142 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b13$$udzne
000169142 7001_ $$0P:(DE-2719)9001603$$aFries, Franca Laura$$b14$$udzne
000169142 7001_ $$aRowe, James B$$b15
000169142 7001_ $$aChurch, Alistair$$b16
000169142 7001_ $$0P:(DE-2719)2811600$$aRespondek, Gesine$$b17$$udzne
000169142 7001_ $$aNewbury, Sarah F$$b18
000169142 7001_ $$00000-0002-6702-0378$$aLeigh, P Nigel$$b19
000169142 7001_ $$aMorris, Huw R$$b20
000169142 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b21$$udzne
000169142 7001_ $$aHafezparast, Majid$$b22
000169142 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms232314554$$gVol. 23, no. 23, p. 14554 -$$n23$$p14554$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
000169142 8564_ $$uhttps://pub.dzne.de/record/169142/files/DZNE-2023-00021.pdf$$yOpenAccess
000169142 8564_ $$uhttps://pub.dzne.de/record/169142/files/DZNE-2023-00021.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000169142 909CO $$ooai:pub.dzne.de:169142$$popenaire$$pdnbdelivery$$pdriver$$pVDB$$popen_access
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811024$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812446$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811226$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002382$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811324$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812665$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814178$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812107$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2380559$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811916$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001603$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811600$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b17$$kDZNE
000169142 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811373$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b21$$kDZNE
000169142 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000169142 9141_ $$y2022
000169142 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-25
000169142 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2022-09-04T08:27:04Z
000169142 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bINT J MOL SCI : 2021$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-09-04T08:27:04Z
000169142 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-09-04T08:27:04Z
000169142 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000169142 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bINT J MOL SCI : 2021$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-25
000169142 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2022-09-04T08:27:04Z
000169142 9201_ $$0I:(DE-2719)1810002$$kAG Dirnagl$$lVascular Pathology$$x0
000169142 9201_ $$0I:(DE-2719)5000007$$kAG Priller$$lTranslational Neuropsychiatry$$x1
000169142 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x2
000169142 9201_ $$0I:(DE-2719)1011101$$kPatient Studies Bonn$$lPatient Studies Bonn$$x3
000169142 9201_ $$0I:(DE-2719)1011401$$kClinical Research Platform (CRP)$$lClinical Research Platform (CRP)$$x4
000169142 9201_ $$0I:(DE-2719)1710012$$kAG Falkenburger$$lTranslational Parkinson Research$$x5
000169142 9201_ $$0I:(DE-2719)1710008$$kAG Donix$$lClinical Planning and Intersite Group$$x6
000169142 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x7
000169142 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x8
000169142 9201_ $$0I:(DE-2719)1110002$$kAG Höglinger 1$$lTranslational Neurodegeneration$$x9
000169142 9201_ $$0I:(DE-2719)1111015$$kClinical Research (Munich)$$lClinical Research (Munich)$$x10
000169142 980__ $$ajournal
000169142 980__ $$aVDB
000169142 980__ $$aI:(DE-2719)1810002
000169142 980__ $$aI:(DE-2719)5000007
000169142 980__ $$aI:(DE-2719)1811005
000169142 980__ $$aI:(DE-2719)1011101
000169142 980__ $$aI:(DE-2719)1011401
000169142 980__ $$aI:(DE-2719)1710012
000169142 980__ $$aI:(DE-2719)1710008
000169142 980__ $$aI:(DE-2719)1510100
000169142 980__ $$aI:(DE-2719)1210000
000169142 980__ $$aI:(DE-2719)1110002
000169142 980__ $$aI:(DE-2719)1111015
000169142 980__ $$aUNRESTRICTED
000169142 9801_ $$aFullTexts