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@ARTICLE{Simoes:169142,
      author       = {Simoes, Fabio A and Joilin, Greig and Peters, Oliver and
                      Schneider, Luisa-Sophie and Priller, Josef and Spruth, Eike
                      Jakob and Vogt, Ina Rosemarie and Kimmich, Okka and Spottke,
                      Annika and Hoffmann, Daniel C and Falkenburger, Björn and
                      Brandt, Moritz and Prudlo, Johannes and Brockmann, Kathrin
                      and Fries, Franca Laura and Rowe, James B and Church,
                      Alistair and Respondek, Gesine and Newbury, Sarah F and
                      Leigh, P Nigel and Morris, Huw R and Höglinger, Günter and
                      Hafezparast, Majid},
      title        = {{P}otential of {N}on-{C}oding {RNA} as {B}iomarkers for
                      {P}rogressive {S}upranuclear {P}alsy.},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {23},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DZNE-2023-00021},
      pages        = {14554},
      year         = {2022},
      abstract     = {Objective markers for the neurodegenerative disorder
                      progressive supranuclear palsy (PSP) are needed to provide a
                      timely diagnosis with greater certainty. Non-coding RNA
                      (ncRNA), including microRNA, piwi-interacting RNA, and
                      transfer RNA, are good candidate markers in other
                      neurodegenerative diseases, but have not been investigated
                      in PSP. Therefore, as proof of principle, we sought to
                      identify whether they were dysregulated in matched serum and
                      cerebrospinal fluid (CSF) samples of patients with PSP.
                      Small RNA-seq was undertaken on serum and CSF samples from
                      healthy controls (n = 20) and patients with PSP (n = 31) in
                      two cohorts, with reverse transcription-quantitative PCR
                      (RT-qPCR) to confirm their dysregulation. Using RT-qPCR, we
                      found in serum significant down-regulation in
                      hsa-miR-92a-3p, hsa-miR-626, hsa-piR-31068, and tRNA-ValCAC.
                      In CSF, both hsa-let-7a-5p and hsa-piR-31068 showed
                      significant up-regulation, consistent with their changes
                      observed in the RNA-seq results. Interestingly, we saw no
                      correlation in the expression of hsa-piR-31068 within our
                      matched serum and CSF samples, suggesting there is no common
                      dysregulatory mechanism between the two biofluids. While
                      these changes were in a small cohort of samples, we have
                      provided novel evidence that ncRNA in biofluids could be
                      possible diagnostic biomarkers for PSP and further work will
                      help to expand this potential.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: diagnosis /
                      Supranuclear Palsy, Progressive: genetics / Biomarkers /
                      MicroRNAs: genetics / Down-Regulation / PSP (Other) /
                      RNA-seq (Other) / biomarker (Other) / non-coding RNA (Other)
                      / progressive supranuclear palsy (Other) / Biomarkers (NLM
                      Chemicals) / MicroRNAs (NLM Chemicals)},
      cin          = {AG Dirnagl / AG Priller / AG Endres / Patient Studies Bonn
                      / Clinical Research Platform (CRP) / AG Falkenburger / AG
                      Donix / AG Teipel / AG Gasser / AG Höglinger 1 / Clinical
                      Research (Munich)},
      ddc          = {540},
      cid          = {I:(DE-2719)1810002 / I:(DE-2719)5000007 /
                      I:(DE-2719)1811005 / I:(DE-2719)1011101 / I:(DE-2719)1011401
                      / I:(DE-2719)1710012 / I:(DE-2719)1710008 /
                      I:(DE-2719)1510100 / I:(DE-2719)1210000 / I:(DE-2719)1110002
                      / I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36498882},
      pmc          = {pmc:PMC9738832},
      doi          = {10.3390/ijms232314554},
      url          = {https://pub.dzne.de/record/169142},
}