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000169151 005__ 20250127111030.0
000169151 0247_ $$2pmc$$apmc:PMC9849315
000169151 0247_ $$2doi$$a10.1007/s00401-022-02524-2
000169151 0247_ $$2pmid$$apmid:36512061
000169151 0247_ $$2ISSN$$a0001-6322
000169151 0247_ $$2ISSN$$a1432-0533
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000169151 037__ $$aDZNE-2023-00030
000169151 041__ $$aEnglish
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000169151 1001_ $$aNelson, Peter T$$b0
000169151 245__ $$aLATE-NC staging in routine neuropathologic diagnosis: an update.
000169151 260__ $$aHeidelberg$$bSpringer$$c2023
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000169151 520__ $$aAn international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful for autopsy practice and dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit with current diagnostic categories. The goal of this report is to update the neuropathologic criteria for the diagnosis and staging of LATE-NC, based primarily on published data. We provide practical suggestions about how to integrate available genetic information and comorbid pathologies [e.g., Alzheimer's disease neuropathologic changes (ADNC) and Lewy body disease]. We also describe recent research findings that have enabled more precise guidance on how to differentiate LATE-NC from other subtypes of TDP-43 pathology [e.g., frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)], and how to render diagnoses in unusual situations in which TDP-43 pathology does not follow the staging scheme proposed in 2019. Specific recommendations are also made on when not to apply this diagnostic term based on current knowledge. Neuroanatomical regions of interest in LATE-NC are described in detail and the implications for TDP-43 immunohistochemical results are specified more precisely. We also highlight questions that remain unresolved and areas needing additional study. In summary, the current work lays out a number of recommendations to improve the precision of LATE-NC staging based on published reports and diagnostic experience.
000169151 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
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000169151 650_7 $$2NLM Chemicals$$aDNA-Binding Proteins
000169151 650_7 $$2Other$$aAging
000169151 650_7 $$2Other$$aDementia
000169151 650_7 $$2Other$$aFTD
000169151 650_7 $$2Other$$aHippocampal sclerosis
000169151 650_7 $$2Other$$aNCI
000169151 650_7 $$2Other$$aNeuroanatomy
000169151 650_7 $$2Other$$aProcesses
000169151 650_7 $$2Other$$aStages
000169151 650_7 $$2Other$$aTDP-43
000169151 650_2 $$2MeSH$$aDementia
000169151 650_2 $$2MeSH$$aHumans
000169151 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000169151 650_2 $$2MeSH$$aFrontotemporal Dementia: pathology
000169151 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: pathology
000169151 650_2 $$2MeSH$$aDNA-Binding Proteins: genetics
000169151 650_2 $$2MeSH$$aTDP-43 Proteinopathies
000169151 7001_ $$aLee, Edward B$$b1
000169151 7001_ $$aCykowski, Matthew D$$b2
000169151 7001_ $$aAlafuzoff, Irina$$b3
000169151 7001_ $$aArfanakis, Konstantinos$$b4
000169151 7001_ $$aAttems, Johannes$$b5
000169151 7001_ $$aBrayne, Carol$$b6
000169151 7001_ $$aCorrada, Maria M$$b7
000169151 7001_ $$aDugger, Brittany N$$b8
000169151 7001_ $$aFlanagan, Margaret E$$b9
000169151 7001_ $$aGhetti, Bernardino$$b10
000169151 7001_ $$aGrinberg, Lea T$$b11
000169151 7001_ $$aGrossman, Murray$$b12
000169151 7001_ $$0P:(DE-2719)2810708$$aGrothe, Michel J$$b13$$udzne
000169151 7001_ $$aHalliday, Glenda M$$b14
000169151 7001_ $$aHasegawa, Masato$$b15
000169151 7001_ $$0P:(DE-2719)9000134$$aHokkanen, Suvi R K$$b16$$udzne
000169151 7001_ $$aHunter, Sally$$b17
000169151 7001_ $$aJellinger, Kurt$$b18
000169151 7001_ $$aKawas, Claudia H$$b19
000169151 7001_ $$aKeene, C Dirk$$b20
000169151 7001_ $$aKouri, Naomi$$b21
000169151 7001_ $$aKovacs, Gabor G$$b22
000169151 7001_ $$aLeverenz, James B$$b23
000169151 7001_ $$aLatimer, Caitlin S$$b24
000169151 7001_ $$0P:(DE-2719)9000939$$aMackenzie, Ian R$$b25$$udzne
000169151 7001_ $$aMao, Qinwen$$b26
000169151 7001_ $$aMcAleese, Kirsty E$$b27
000169151 7001_ $$aMerrick, Richard$$b28
000169151 7001_ $$aMontine, Thomas J$$b29
000169151 7001_ $$aMurray, Melissa E$$b30
000169151 7001_ $$aMyllykangas, Liisa$$b31
000169151 7001_ $$aNag, Sukriti$$b32
000169151 7001_ $$aNeltner, Janna H$$b33
000169151 7001_ $$aNewell, Kathy L$$b34
000169151 7001_ $$aRissman, Robert A$$b35
000169151 7001_ $$aSaito, Yuko$$b36
000169151 7001_ $$aSajjadi, S Ahmad$$b37
000169151 7001_ $$aSchwetye, Katherine E$$b38
000169151 7001_ $$aTeich, Andrew F$$b39
000169151 7001_ $$aThal, Dietmar R$$b40
000169151 7001_ $$aTomé, Sandra O$$b41
000169151 7001_ $$aTroncoso, Juan C$$b42
000169151 7001_ $$aWang, Shih-Hsiu J$$b43
000169151 7001_ $$aWhite, Charles L$$b44
000169151 7001_ $$aWisniewski, Thomas$$b45
000169151 7001_ $$aYang, Hyun-Sik$$b46
000169151 7001_ $$aSchneider, Julie A$$b47
000169151 7001_ $$aDickson, Dennis W$$b48
000169151 7001_ $$0P:(DE-2719)2810592$$aNeumann, Manuela$$b49$$eLast author$$udzne
000169151 773__ $$0PERI:(DE-600)1458410-4$$a10.1007/s00401-022-02524-2$$gVol. 145, no. 2, p. 159 - 173$$n2$$p159 - 173$$tActa neuropathologica$$v145$$x0001-6322$$y2023
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