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@ARTICLE{Nelson:169151,
      author       = {Nelson, Peter T and Lee, Edward B and Cykowski, Matthew D
                      and Alafuzoff, Irina and Arfanakis, Konstantinos and Attems,
                      Johannes and Brayne, Carol and Corrada, Maria M and Dugger,
                      Brittany N and Flanagan, Margaret E and Ghetti, Bernardino
                      and Grinberg, Lea T and Grossman, Murray and Grothe, Michel
                      J and Halliday, Glenda M and Hasegawa, Masato and Hokkanen,
                      Suvi R K and Hunter, Sally and Jellinger, Kurt and Kawas,
                      Claudia H and Keene, C Dirk and Kouri, Naomi and Kovacs,
                      Gabor G and Leverenz, James B and Latimer, Caitlin S and
                      Mackenzie, Ian R and Mao, Qinwen and McAleese, Kirsty E and
                      Merrick, Richard and Montine, Thomas J and Murray, Melissa E
                      and Myllykangas, Liisa and Nag, Sukriti and Neltner, Janna H
                      and Newell, Kathy L and Rissman, Robert A and Saito, Yuko
                      and Sajjadi, S Ahmad and Schwetye, Katherine E and Teich,
                      Andrew F and Thal, Dietmar R and Tomé, Sandra O and
                      Troncoso, Juan C and Wang, Shih-Hsiu J and White, Charles L
                      and Wisniewski, Thomas and Yang, Hyun-Sik and Schneider,
                      Julie A and Dickson, Dennis W and Neumann, Manuela},
      title        = {{LATE}-{NC} staging in routine neuropathologic diagnosis:
                      an update.},
      journal      = {Acta neuropathologica},
      volume       = {145},
      number       = {2},
      issn         = {0001-6322},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2023-00030},
      pages        = {159 - 173},
      year         = {2023},
      abstract     = {An international consensus report in 2019 recommended a
                      classification system for limbic-predominant age-related
                      TDP-43 encephalopathy neuropathologic changes (LATE-NC). The
                      suggested neuropathologic staging system and nomenclature
                      have proven useful for autopsy practice and dementia
                      research. However, some issues remain unresolved, such as
                      cases with unusual features that do not fit with current
                      diagnostic categories. The goal of this report is to update
                      the neuropathologic criteria for the diagnosis and staging
                      of LATE-NC, based primarily on published data. We provide
                      practical suggestions about how to integrate available
                      genetic information and comorbid pathologies [e.g.,
                      Alzheimer's disease neuropathologic changes (ADNC) and Lewy
                      body disease]. We also describe recent research findings
                      that have enabled more precise guidance on how to
                      differentiate LATE-NC from other subtypes of TDP-43
                      pathology [e.g., frontotemporal lobar degeneration (FTLD)
                      and amyotrophic lateral sclerosis (ALS)], and how to render
                      diagnoses in unusual situations in which TDP-43 pathology
                      does not follow the staging scheme proposed in 2019.
                      Specific recommendations are also made on when not to apply
                      this diagnostic term based on current knowledge.
                      Neuroanatomical regions of interest in LATE-NC are described
                      in detail and the implications for TDP-43
                      immunohistochemical results are specified more precisely. We
                      also highlight questions that remain unresolved and areas
                      needing additional study. In summary, the current work lays
                      out a number of recommendations to improve the precision of
                      LATE-NC staging based on published reports and diagnostic
                      experience.},
      keywords     = {Dementia / Humans / Alzheimer Disease: pathology /
                      Frontotemporal Dementia: pathology / Amyotrophic Lateral
                      Sclerosis: pathology / DNA-Binding Proteins: genetics /
                      TDP-43 Proteinopathies / DNA-Binding Proteins (NLM
                      Chemicals) / Aging (Other) / Dementia (Other) / FTD (Other)
                      / Hippocampal sclerosis (Other) / NCI (Other) / Neuroanatomy
                      (Other) / Processes (Other) / Stages (Other) / TDP-43
                      (Other)},
      cin          = {AG Neumann},
      ddc          = {610},
      cid          = {I:(DE-2719)1210003},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9849315},
      pubmed       = {pmid:36512061},
      doi          = {10.1007/s00401-022-02524-2},
      url          = {https://pub.dzne.de/record/169151},
}